Protective molecular mechanisms of clusterin against apoptosis in cardiomyocytes

Author(s)

Pereira, Rodrigo Martins ^{[1, 2]} ; Mekary, Rania A. ^{[3, 4]} ; da Cruz Rodrigues, Kellen Cristina ^{[1, 2]} ; Anaruma, Chadi Pellegrini ^{[1, 2]} ; Ropelle, Eduardo Rochete ^{[1, 2]} ; Ramos da Silva, Adelino Sanchez ^[5] ; Cintra, Dennys Esper ^[1] ; Pauli, Jose Rodrigo ^{[1, 2]} ; de Moura, Leandro Pereira ^{[1, 2]}

Affiliation

^[1] Univ Estadual Campinas, Sch Appl Sci, Lab Mol Biol Exercise LaBMEx, 1300 Pedro Zaccaria St, Sao Paulo - Brazil

^[2] Univ Campinas UNICAMP, Sch Appl Sci, CEPECE Ctr Res Sport Sci, Sao Paulo - Brazil

^[3] MCPHS Univ, Dept Pharmaceut Business & Adm Sci, Boston, MA - USA

^[4] Harvard Med Sch, Brigham & Womens Hosp, Dept Surg, Boston, MA - USA

^[5] Univ Sao Paulo, Sch Phys Educ & Sport Ribeiro Preto, Sao Paulo - Brazil

• Document type: Review article
• Source: HEART FAILURE REVIEWS; v. 23, n. 1, p. 123-129, JAN 2018.
• Web of Science Citations: 6

Abstract

Loss of cardiomyocytes occurs with aging and contributes to cardiovascular complications. In the present study, we highlighted the role of clusterin, a protein that has recently been associated with the protection of cardiomyocytes from apoptosis. Clusterin protects cardiac cells against damage from myocardial infarction, transplant, or myocarditis. Clusterin can act directly or indirectly on apoptosis by regulating several intracellular pathways. These pathways include (1) the oxidant and inflammatory program, (2) insulin growth factor 1 (IGF-1) pathway, (3) KU70 / BCL-2-associated X protein (BAX) pathway, (4) tumor necrosis factor alpha (TNF-alpha) pathway, (5) BCL-2 antagonist of cell death (BAD) pathway, and (6) mitogen-activated protein kinase (MAPK) pathway. Given the key role of clusterin in preventing loss of cardiac tissue, modulating the expression and function of this protein carries the potential of improving cardiovascular care in the future. (AU)

• FAPESP's process: 15/07199-2 - Role of clusterin/ApoJ on insulin signalling in response to physical exercise in rodents and humans
• Grantee: Leandro Pereira de Moura
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 16/12569-6 - Effects of different exercise intensities on clusterin metabolism and its interference on insulin signaling in rodents
• Grantee: Rodrigo Martins Pereira
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)