Lipid parameters in obese and normal weight patients with or without chronic periodontitis

Author(s)

Cury, Eduardo Zaccarias ^[1] ; Santos, Vanessa Renata ^[1] ; Maciel, Suellen da Silva ^[1] ; Dias Goncalves, Tiago Eduardo ^{[2, 1]} ; Zimmermann, Glaucia Santos ^[1] ; Salani Mota, Rosa Maria ^[3] ; Figueiredo, Luciene Cristina ^[1] ; Duarte, Poliana Mendes ^[1]

Affiliation

^[1] Univ Guarulhos, Dept Periodontol, Sao Paulo - Brazil

^[2] Univ Fed Santa Catarina, Dept Dent, Florianopolis, SC - Brazil

^[3] Univ Fed Ceara, Dept Stat & Appl Math, Fortaleza, Ceara - Brazil

• Document type: Journal article
• Source: CLINICAL ORAL INVESTIGATIONS; v. 22, n. 1, p. 161-167, JAN 2018.
• Web of Science Citations: 6

Abstract

The aim of this study was to evaluate the serum levels of lipids in patients with normal weight (NW) or obesity with or without chronic periodontitis (ChP). One hundred and sixty non-smoking patients without history of diabetes and/or cardiovascular events were allocated into one of the following groups: NW patients with periodontal health (NWH; n = 40), NW patients with ChP (NWChP; n = 40), obese patients with periodontal health (ObH; n = 40), and obese patients with ChP (ObChP; n = 40). Serum levels of total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides (TRG) were estimated. After adjustments for gender and age, both NW groups presented lower levels of TRG than both obese groups (p < 0.05). The NWH group presented lower levels of LDL than both periodontitis groups (p < 0.05) and the lowest TC/HDL ratio when compared to the other groups (p < 0.05). Females from the NWH group exhibited higher levels of HDL and lower LDL/HDL ratio than females from the ObChP group (p < 0.05). Furthermore, individuals from the ObChP group were more likely to have levels of LDL >= 130 mg/dl and HDL <= 40 mg/dl, compared to those from the NWH group (p < 0.05). ChP and obesity, jointly or individually, are associated with undesirable pro-atherogenic lipid profiles. There is interest in identifying clinical conditions associated with dyslipidemia to improve preventive and treatment strategies. This study demonstrated that ChP, obesity, and the association of both conditions might be related to pro-atherogenic lipid profiles. (AU)

• FAPESP's process: 10/01930-3 - Adipocytokines in periodontally-healthy and chronic periodontitis obese subjects
• Grantee: Poliana Mendes Duarte
• Support Opportunities: Regular Research Grants