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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sensitive voltammetric determination of hydroxyzine and its main metabolite cetirizine and identification of oxidation products by nuclear magnetic resonance spectroscopy

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Author(s):
Lourencao, Bruna Claudia [1] ; Silva, Tiago Almeida [1] ; Santos, Maiara da Silva [1] ; Ferreira, Antonio Gilberto [1] ; Fatibello-Filho, Orlando [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Carlos, Dept Chem, Washington Luis Km 235, POB 676, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF ELECTROANALYTICAL CHEMISTRY; v. 807, p. 187-195, DEC 15 2017.
Web of Science Citations: 3
Abstract

The electrochemical detection and electrooxidation path of the first-generation antihistamine receptor hydroxyzine (HDZ) and its main metabolite cetirizine (CTZ) are addressed in this research. A carbon black-modified electrode to explore the electrochemical responsivity and electroanalytical detection of HDZ and CTZ was designed. Compared to the bare electrode, the irreversible anodic responses observed for HDZ and CTZ were considerably improved on the proposed carbon black-modified electrode, including twenty times enhancement of the anodic peak currents and the shifting of anodic peak potentials to less positive potentials. In order to identify the electrooxidation products resulting from the previously verified irreversible redox processes, cyclic voltammetric studies and potentiostatic electrolysis assays followed by products identification by nuclear magnetic resonance (NMR) spectroscopy were carried out. From the combination of electrochemistry and NMR spectroscopy data it was possible to propose electrooxidation reaction mechanisms for HDZ and CTZ molecules. By applying square-wave adsorptive anodic stripping voltammetry (SWAdASV) under optimized experimental conditions, the obtained analytical curves for HDZ and CTZ were linear from 2.99 x 10(-7) to 9.81 x 10(-6) mol L-1 and from 4.97 x 10(-7) to 1.08 x 10(-5) mol L-1, with limits of detection of 1.00 x 10(-7) mol L-1 and 4.00 x 10(-7) mot L-1, respectively. Finally, spiked synthetic human biological fluids were analysed by the proposed SWAdASV procedures, with recovery percentages close to 100%. (AU)

FAPESP's process: 14/03019-7 - Evaluation and analytical application of boron doped diamond porous electrodes for voltammetric determination of biomolecules, ascorbic acid, uric acid, dopamine and adrenaline in biological fluids and/or pharmaceutical formulations
Grantee:Bruna Cláudia Lourenção
Support Opportunities: Scholarships in Brazil - Post-Doctoral