A PLAG1 mutation contributed to stature recovery in modern cattle

Author(s):Show less -

Utsunomiya, Yuri Tani ^{[1, 2]} ; Milanesi, Marco ^{[1, 3, 4, 5]} ; Harth Utsunomiya, Adam Taiti ^{[1, 3]} ; Pintor Torrecilha, Rafaela Beatriz ^{[1, 2]} ; Kim, Eui-Soo ^[6] ; Costa, Marcio Silva ^[7] ; Aguiar, Tamiris Sayuri ^{[1, 2]} ; Schroeder, Steven ^[8] ; do Carmo, Adriana Santana ^[9] ; Carvalheiro, Roberto ^[10] ; Rezende Neves, Haroldo Henrique ^[11] ; Morozini Padula, Romulo Claudio ^[12] ; Sussai, Thayla Souza ^[12] ; Zavarez, Ludmilla Balbo ^{[1, 2]} ; Cipriano, Rafael Silva ^[12] ; Theodoro Caminhas, Maria Margareth ^[3] ; Hambrecht, George ^[13] ; Colli, Licia ^{[4, 5]} ; Eufemi, Elisa ^{[4, 5]} ; Ajmone-Marsan, Paolo ^{[4, 5]} ; Cesana, Deneb ^[14] ; Sannazaro, Marco ^[14] ; Buora, Maurizio ^[15] ; Morgante, Michele ^{[16, 17]} ; Liu, George ^[8] ; Bickhart, Derek ^[8] ; Van Tassell, Curtis Paul ^[8] ; Solkner, Johann ^[18] ; Sonstegard, Tad Stewart ^[6] ; Garcia, Jose Fernando ^{[1, 3, 2]}

Affiliation:Show less -

^[1] IAEA, Collaborating Ctr Anim Genom & Bioinformat, Aracatuba, SP - Brazil

^[2] Sao Paulo State Univ Unesp, Sch Agr & Veterinarian Sci, Dept Prevent Vet Med & Anim Reprod, Jaboticabal, SP - Brazil

^[3] Sao Paulo State Univ Unesp, Sch Vet Med, Dept Support Prod & Anim Hlth, Aracatuba, SP - Brazil

^[4] Univ Cattolica Sacro Cuore, Ist Zootecn, Piacenza - Italy

^[5] Univ Cattolica Sacro Cuore, BioDNA Ctr Ric Biodiversita & DNA Ant, Piacenza - Italy

^[6] Recombinetics Inc, St Paul, MN 55104 - USA

^[7] UFPI Univ Fed Piaui, Teresina, Piaui - Brazil

^[8] ARS, Anim Genom & Improvement Lab, USDA, Beltsville, MD - USA

^[9] Univ Fed Goias, EVZ, Campus Samambaia, Goiania, Go - Brazil

^[10] Sao Paulo State Univ Unesp, Sch Agr & Veterinarian Sci, Dept Anim Sci, Jaboticabal, SP - Brazil

^[11] GenSys Consultores Associados, Porto Alegre, RS - Brazil

^[12] Ctr Univ Catolico Salesiano, Aracatuba, SP - Brazil

^[13] Univ Maryland, Dept Anthropol, College Pk, MD 20742 - USA

^[14] Univ Cattolica Sacro Cuore, Fac Lettere & Filosofia, Dipartimento Storia Archeol & Storia & Arte, Milan - Italy

^[15] Soc Friulana Archeol, Udine - Italy

^[16] Ist Genom Applicata, Udine - Italy

^[17] Univ Udine, Dipartamento Sci Agr & Ambientali, Udine - Italy

^[18] BOKU Univ Nat Resources & Life Sci, Dept Sustainable Agr Syst, Div Livestock Sci, Vienna - Austria

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 7, DEC 7 2017.
• Web of Science Citations: 13

Abstract

The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of similar to 1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a > 1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16th and 18th centuries. Towards the 19th and 20th centuries, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait. (AU)

• FAPESP's process: 10/52030-2 - Genome wide association study for reproductive traits in zebu bulls (Bos indicus) using high-density SNP chip
• Grantee: José Fernando Garcia
• Support type: Regular Research Grants
• FAPESP's process: 14/01095-8 - Use of next generation sequencing for the fine mapping of loci explaining variance in scrotal circumference in Nellore cattle
• Grantee: Yuri Tani Utsunomiya
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 16/07531-0 - Comparison of methods for admixture and heterosis mapping in crossbred cattle populations
• Grantee: Yuri Tani Utsunomiya
• Support type: Scholarships abroad - Research Internship - Doctorate