Time to Optimize Supplementation: Modifying Factors Influencing the Individual Responses to Extracellular Buffering Agents

Author(s)

Heibel, Andre B. ^{[1, 2]} ; Perim, Pedro H. L. ^{[3, 1]} ; Oliveira, Luana F. ^{[4, 1]} ; McNaughton, Lars R. ^{[5, 6]} ; Saunders, Bryan ^{[7, 1, 8]}

Affiliation

^[1] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Sao Paulo - Brazil

^[2] Univ Brasilia, Lab Nutr Biochem, Brasilia, DF - Brazil

^[3] Sao Camilo Univ Ctr, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil

^[5] Edge Hill Univ, Dept Sport & Phys Act, Sports Nutr & Performance Grp, Ormskirk - England

^[6] Univ Johannesburg, Fac Hlth Sci, Dept Sport & Movement Studies, Johannesburg - South Africa

^[7] Univ Sao Paulo, Fac Med, Rheumatol Div, Sao Paulo - Brazil

^[8] Univ Sao Paulo, Fac Med, Inst Orthopaed & Traumatol, Sao Paulo - Brazil

• Document type: Review article
• Source: FRONTIERS IN NUTRITION; v. 5, MAY 8 2018.
• Web of Science Citations: 5

Abstract

Blood alkalosis, as indicated by an increased blood bicarbonate concentration and pH, has been shown to be beneficial for exercise performance. Sodium bicarbonate, sodium citrate, and sodium or calcium lactate, can all result in increased circulating bicarbonate and have all independently been shown to improve exercise capacity and performance under various circumstances. Although there is considerable evidence demonstrating the efficacy of these supplements in several sports-specific situations, it is commonly acknowledged that their efficacy is equivocal, due to contrasting evidence. Herein, we discuss the physiological and environmental factors that may modify the effectiveness of these supplements including, (i) absolute changes in circulating bicarbonate; (ii) supplement timing, (iii) the exercise task performed, (iv) monocarboxylate transporter (MCT) activity; (v) training status, and (vi) associated side-effects. The aim of this narrative review is to highlight the factors which may modify the response to these supplements, so that individuals can use this information to attempt to optimize supplementation and allow the greatest possibility of an ergogenic effect. (AU)

• FAPESP's process: 16/17391-0 - Carnosine metabolism in skeletal muscle: a multi-approach study
• Grantee: Pedro Henrique Lopes Perim
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 17/04973-4 - Nutritional supplementation and exercise to optimise exercise performance: focus on individual responses and a step towards personalized sports nutrition
• Grantee: Bryan Saunders
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 16/50438-0 - Nutritional suplementation and exercise to optimize exercise performance: focus on individual responses and a step towards personalized sports nutrition
• Grantee: Bryan Saunders
• Support Opportunities: Research Grants - Young Investigators Grants