Synthesis and 3D Interconnected Nanostructured h-BN-Based Biocomposites by Low-Temperature Plasma Sintering: Bone Regeneration Applications

Author(s):Show less -

Gautam, Chandkiram ^{[1, 2]} ; Chakravarty, Dibyendu ^{[3, 4]} ; Gautam, Amarendra ^[1] ; Tiwary, Chandra Sekhar ^{[2, 4]} ; Woellner, Cristiano Francisco ^{[2, 5]} ; Mishra, Vijay Kumar ^[6] ; Ahmad, Naseer ^[6] ; Ozden, Sehmus ^[2] ; Jose, Sujin ^[7] ; Biradar, Santoshkumar ^[2] ; Vajtai, Robert ^[2] ; Trivedi, Ritu ^[6] ; Galvao, Douglas S. ^[5] ; Ajayan, Pulickel M. ^[2]

Affiliation

^[1] Univ Lucknow, Dept Phys, Lucknow 226007, Uttar Pradesh - India

^[2] Rice Univ, Dept Mat Sci & Nano Engn, Houston, TX 77005 - USA

^[3] Int Adv Res Ctr Powder Met & New Mat ARCI, Hyderabad 500005, Telangana - India

^[4] Indian Inst Technol, Dept Mat Sci & Engn, Gandhinagar, Gujarat - India

^[5] Univ Estadual Campinas, UNICAMP, Appl Phys Dept, BR-13083859 Campinas, SP - Brazil

^[6] CSIR Cent Drug Res Inst, Endocrinol Div, Lucknow 226031, Uttar Pradesh - India

^[7] Madurai Kamaraj Univ, Sch Phys, Madurai 625021, Tamil Nadu - India

• Document type: Journal article
• Source: ACS OMEGA; v. 3, n. 6, p. 6013-6021, JUN 2018.
• Web of Science Citations: 5

Abstract

Recent advances and demands in biomedical applications drive a large amount of research to synthesize easily scalable low-density, high-strength, and wear-resistant biomaterials. The chemical inertness with low density combined with high strength makes h-BN one of the promising materials for such application. In this work, three-dimensional hexagonal boron nitride (h-BN) interconnected with boron trioxide (B2O3) was prepared by easily scalable and energy efficient spark plasma sintering (SPS) process. The composite structure shows significant densification (1.6-1.9 g/cm(3)) and high surface area (0.97-14.5 m(2)/g) at an extremely low SPS temperature of 250 degrees C. A high compressive strength of 291 MPa with a reasonably good wear resistance was obtained for the composite structure. The formation of strong covalent bonds between h-BN and B2O3 was formulated and established by molecular dynamics simulation. The composite showed significant effect on cell viability/proliferation. It shows a high mineralized nodule formation over the control, which suggests its use as a possible osteogenic agent in bone formation. (AU)

• FAPESP's process: 16/12340-9 - Structural and mechanical properties of carbon-based foams
• Grantee: Cristiano Francisco Woellner
• Support type: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 13/08293-7 - CCES - Center for Computational Engineering and Sciences
• Grantee: Munir Salomao Skaf
• Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC