Heart rate variability in individuals with Down syndrome - A systematic review and meta-analysis

Author(s)

de Carvalho, Tatiana Dias ^{[1, 2]} ; Massetti, Thais ^[3] ; da Silva, Talita Dias ^[1] ; Crocetta, Tania Brusque ^[4] ; Guarnieri, Regiani ^[4] ; Marques Vanderlei, Luiz Carlos ^[5] ; de Mello Monteiro, Carlos Bandeira ^[3] ; Garner, David M. ^[6] ; Ferreira, Celso ^[1]

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Dept Med, Disciplina Cardiol, Sao Paulo - Brazil

^[2] UNLaM, Dept Ciencias Salud Kinesiol & Fisiatria, San Justo, BA - Argentina

^[3] Univ Sao Paulo, Fac Med, Programa Posgrad Ciencias Reabilitacao, Sao Paulo, SP - Brazil

^[4] FMABC, Lab Escrita Cientif, Santo Andre, SP - Brazil

^[5] Univ Estadual Paulista Unesp, Dept Fisioterapia, Fac Ciencias & Tecnol, Presidente Prudente, SP - Brazil

^[6] Oxford Brookes Univ, Dept Biol & Med Sci, Cardioresp Res Grp, Headington Campus, Gipsy Lane, Oxford OX3 0BP - England

• Document type: Review article
• Source: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 213, p. 23-33, SEP 2018.
• Web of Science Citations: 3

Abstract

Introduction: Down syndrome (DS) results in many changes, including dysfunction in cardiac autonomic modulation. Heart rate variability (HRV) analysis evaluates the autonomic function and it is a predictor of adverse cardiovascular events. Objective: To present results of a systematic review and a meta-analysis about heart rate variability in individuals with DS. Method: A systematic review was performed on PubMed, PubMed Central and Web of science databases. We included articles that exhibited all the terms: ``Down Syndrome{''}, ``heart rate variability{''}, ``autonomic nervous system{''}, ``autonomic dysfunction{''} and ``cardiac autonomic modulation{''}. We conducted the meta-analysis to compare ``DS{''} to ``controls{''} during rest. Random effects models were used, as were appropriate tests for heterogeneity. Results: From 271 studies, 13 were included in our review. These are conducted with volunteers from a wide age range, of either gender, and not taking medications. Meta -analysis displayed that there were no significant differences between the groups at rest, except the RMSSD, which revealed a significant (Z = -2.80, p = 0.005) main effect (Hedge's g = -0.55, 95% CI {[}0.93; -0.16]), indicating difference in individuals with DS compared with controls. Conclusion: There is autonomic dysfunction in individuals with DS, which may or may not be expressed at rest, but it is usually demonstrated in an autonomic task. Meta -analysis specified that there was no significant alteration between DS and the controls during rest, except RMSSD index which was lower in DS than controls. (AU)

• FAPESP's process: 10/18005-0 - CHARACTERIZATION OF AUTONOMIC MODULATION AND ANTHROPOMETRIC PROFILE OF CHILDREN WITH DOWN SYNDROME
• Grantee: Tatiana Dias de Carvalho
• Support Opportunities: Scholarships in Brazil - Doctorate