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A SYSTEMATIC REVIEW AND META-ANALYSIS OF THE ASSOCIATION BETWEEN POLYMORPHISMS IN MATERNAL GENES INVOLVED IN FOLATE METABOLISM AND THE BIRTH OF INDIVIDUALS WITH DOWN SYNDROME.

Grant number: 12/04713-9
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2012
Effective date (End): July 31, 2014
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal researcher:Erika Cristina Pavarino
Grantee:Daniella Balduino Victorino
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil

Abstract

Down Syndrome is the most common cause mental deficiency of genetic etiology, present in approximately one case per 600-700 births, making it the most common condition of aneuploidy compatible with life. In 95% of cases, is attributed to free trisomy of chromosome 21 resulting from maternal meiotic nondisjunction.It is well established that advanced maternal age is a risk factor for non-disjunction, however other etiological factors independent of maternal age are also related to the occurrence of Down syndrome. Among these factors, is hypomethylation of centromeric DNA as a consequence of abnormal folate metabolism, and polymorphisms in genes encoding enzymes involved in metabolism, have been suggested as maternal risk factors for the syndrome. Genetic polymorphisms may alter the resulting products of the folate metabolic pathway and result in DNA hypomethylation, genomic instability and reduced DNA repair capacity. Studies investigating the association between genetic polymorphisms involved in folate metabolic pathway and Down syndrome, report contradictory or inconclusive results. Therefore, the aim of this study is to determine, through systematic review and meta-analysis, the presence of polymorphisms in folate metabolic pathway have genetic risk factors for birth mothers of children with Down syndrome, based on best available evidence in literature.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VICTORINO, DANIELLA BALDUINO; DE GODOY, MOACIR FERNANDES; GOLONI-BERTOLLO, ENY MARIA; PAVARINO, ERIKA CRISTINA. Genetic Polymorphisms Involved in Folate Metabolism and Maternal Risk for Down Syndrome: A Meta-Analysis. DISEASE MARKERS, p. 1-12, . (12/04713-9)
VICTORINO, D. B.; GODOY, M. F.; GOLONI-BERTOLLO, E. M.; PAVARINO, E. C.. Meta-analysis of Methylenetetrahydrofolate reductase maternal gene in Down syndrome: increased susceptibility in women carriers of the MTHFR 677T allele. MOLECULAR BIOLOGY REPORTS, v. 41, n. 8, p. 5491-5504, . (12/04664-8, 12/04713-9)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.