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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Isolation, synthesis and bioactivity studies of phomactin terpenoids

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Kuroda, Yusuke [1] ; Nicacio, Karen J. [2] ; da Silva-, Jr., Ildefonso Alves [3] ; Leger, Paul R. [1] ; Chang, Stanley [1] ; Gubiani, Juliana R. [2] ; Deflon, Victor M. [2] ; Nagashima, Nozomu [1] ; Rode, Alexander [1] ; Blackford, Katherine [1] ; Ferreira, Antonio G. [4] ; Sette, Lara D. [5] ; Williams, David E. [6, 7] ; Andersen, Raymond J. [6, 7] ; Jancar, Sonia [3] ; Berlinck, Roberto G. S. [2] ; Sarpong, Richmond [1]
Total Authors: 17
[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 - USA
[2] Univ Sao Paulo, Inst Quim Sao Carlos, Sao Carlos, SP - Brazil
[3] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Carlos, Dept Quim, Sao Carlos, SP - Brazil
[5] Univ Estadual Paulista, Inst Biociencias, Dept Bioquim & Microbiol, Campus Rio Claro, Rio Claro, SP - Brazil
[6] Univ British Columbia, Dept Earth Ocean & Atmospher Sci, Vancouver, BC - Canada
[7] Univ British Columbia, Dept Chem, Vancouver, BC - Canada
Total Affiliations: 7
Document type: Journal article
Source: NATURE CHEMISTRY; v. 10, n. 9, p. 938-945, SEP 2018.
Web of Science Citations: 7

Studies of secondary metabolites (natural products) that cover their isolation, chemical synthesis and bioactivity investigation present myriad opportunities for discovery. For example, the isolation of novel secondary metabolites can inspire advances in chemical synthesis strategies to achieve their practical preparation for biological evaluation. In the process, chemical synthesis can also provide unambiguous structural characterization of the natural products. Although the isolation, chemical synthesis and bioactivity studies of natural products are mutually beneficial, they are often conducted independently. Here, we demonstrate the benefits of a collaborative study of the phomactins, diterpenoid fungal metabolites that serve as antagonists of the platelet activating factor receptor. Our isolation of novel phomactins has spurred the development of a bioinspired, unified approach that achieves the total syntheses of six congeners. We also demonstrate in vitro the beneficial effects of several phomactins in suppressing the rate of repopulation of tumour cells following gamma radiation therapy. (AU)

FAPESP's process: 13/50228-8 - Biodiversity components, and its metabolic characters, of Brazilian Islands
Grantee:Roberto Gomes de Souza Berlinck
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 15/01017-0 - Multi-use instrument approved and awarded in the project 2013/50228-8, name of instrument: ultra-performance liquid chromatograph coupled with a high resolution mass spectrometer
Grantee:Roberto Gomes de Souza Berlinck
Support type: Multi-user Equipment Program
FAPESP's process: 17/06014-4 - New secondary metabolites of endophytic and marine organisms as proteasome inhibitors: a validated target against cancer
Grantee:Juliana Regina Gubiani
Support type: Scholarships in Brazil - Post-Doctorate