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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sepsis-induced acute kidney injury: kidney protection effects by antioxidants

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Author(s):
Vasco, Carolina Ferreira [1] ; Watanabe, Mirian [1] ; da Fonseca, Cassiane Dezoti [1] ; Fernandes Vattimo, Maria de Fatima [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Nursing, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Revista Brasileira de Enfermagem; v. 71, n. 4, p. 1921-1927, JUL-AUG 2018.
Web of Science Citations: 2
Abstract

Objective: To evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in an experimental model of sepsis-induced acute kidney injury in rats. Methods: The study used 20 Wistar adult male rats divided into the following groups: control (laparotomy with no induction of abdominal sepsis), sepsis (experimental model of sepsis with cecal ligation and puncture), N-acetylcysteine + sepsis and diosmin-hesperidin + sepsis. The evaluation contemplated physiological parameters (temperature, glycemia, and average blood pressure), kidney function (creatinine clearance), oxidative stress (urinary peroxides) and kidney histology. Results: The animals submitted to cecal ligation and puncture (sepsis) presented lower body temperature, lower average blood pressure, reduced creatinine clearance and increased urinary hydrogen peroxide levels. Treatment with diosmin-hesperidin improved kidney function and led to a reduction in the excretion of oxidative metabolites. Conclusion: The present study highlighted the protective antioxidant action of diosmin-hesperidin in the experimental model of sepsis-induced acute kidney injury. (AU)

FAPESP's process: 13/26560-2 - Iodinated contrast induced acute kidney injury in diabetic and nephropathy diabetic in rats
Grantee:Maria de Fatima Fernandes Vattimo
Support type: Regular Research Grants
FAPESP's process: 11/24028-6 - EFFECT OF PHOSPHODIESTERASE-5 INIBITOR IN ISCHEMIC ACUTE KIDNEY INJURY IN RATS
Grantee:Mirian Watanabe
Support type: Scholarships in Brazil - Post-Doctorate