| Full text | |
| Author(s): |
Vasco, Carolina Ferreira
[1]
;
Watanabe, Mirian
[1]
;
da Fonseca, Cassiane Dezoti
[1]
;
Fernandes Vattimo, Maria de Fatima
[1]
Total Authors: 4
|
| Affiliation: | [1] Univ Sao Paulo, Sch Nursing, Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | Revista Brasileira de Enfermagem; v. 71, n. 4, p. 1921-1927, JUL-AUG 2018. |
| Web of Science Citations: | 2 |
| Abstract | |
ABSTRACT Objective: To evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in an experimental model of sepsis-induced acute kidney injury in rats. Methods: The study used 20 Wistar adult male rats divided into the following groups: control (laparotomy with no induction of abdominal sepsis), sepsis (experimental model of sepsis with cecal ligation and puncture), N-acetylcysteine + sepsis and diosmin-hesperidin + sepsis. The evaluation contemplated physiological parameters (temperature, glycemia, and average blood pressure), kidney function (creatinine clearance), oxidative stress (urinary peroxides) and kidney histology. Results: The animals submitted to cecal ligation and puncture (sepsis) presented lower body temperature, lower average blood pressure, reduced creatinine clearance and increased urinary hydrogen peroxide levels. Treatment with diosmin-hesperidin improved kidney function and led to a reduction in the excretion of oxidative metabolites. Conclusion: The present study highlighted the protective antioxidant action of diosmin-hesperidin in the experimental model of sepsis-induced acute kidney injury. (AU) | |
| FAPESP's process: | 11/24028-6 - EFFECT OF PHOSPHODIESTERASE-5 INIBITOR IN ISCHEMIC ACUTE KIDNEY INJURY IN RATS |
| Grantee: | Mirian Watanabe |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/26560-2 - Iodinated contrast induced acute kidney injury in diabetic and nephropathy diabetic in rats |
| Grantee: | Maria de Fatima Fernandes Vattimo |
| Support Opportunities: | Regular Research Grants |