Contributions from the ovarian follicular environment to oocyte function

Author(s)

del Collado, Maite ^[1] ; Andrade, Gabriella Mamede ^[1] ; Meirelles, Flavio Vieira ^[1] ; da Silveira, Juliano Coelho ^[1] ; Perecin, Felipe ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, Pirassununga, SP - Brazil

• Document type: Journal article
• Source: ANIMAL REPRODUCTION; v. 15, n. 3, p. 261-270, JUL-SEP 2018.
• Web of Science Citations: 2

Abstract

The magnitude of oocyte's role for embryo development is categorical. This unique cell contains the machineries and cellular components necessary to remodel male and female chromatin, to sustain early development and to, ultimately, generate a complete and complex individual. However, to gain these competences before fertilization, the oocyte undergoes several morphological, cellular and molecular changes during its lifetime enclosed in the ovarian follicle. This review will briefly revisit how the oocyte orchestrate the follicular cells, and how molecules transit to the oocyte from the innermost (cumulus) and outermost (antrum and granulosa cells) layers surrounding the follicle-enclosed oocyte. Finally, we will discuss the interferences of in vitro culture conditions in the communication of the oocyte with its surrounding cells and the potential strategies to modulate these communication systems to increase oocyte competence. (AU)

• FAPESP's process: 17/19825-0 - Mechanisms of oocyte lipid accumulation in obesity
• Grantee: Maite Del Collado Barrondo
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 14/21034-3 - Intra and intercellular routes during foliculogenesis and in vivo and in vitro oocyte maturation
• Grantee: Felipe Perecin
• Support type: Regular Research Grants
• FAPESP's process: 18/01431-9 - PI3K-Akt signaling pathway effect in oocyte maturation and early embryo development in cattle
• Grantee: Gabriella Mamede Andrade
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 14/22887-0 - Cell-secreted vesicles containing miRNAs modulate epigenetic changes during in vitro culture of bovine gametes and embryos
• Grantee: Juliano Coelho da Silveira
• Support type: Research Grants - Young Investigators Grants
• FAPESP's process: 13/08135-2 - CTC - Center for Cell-Based Therapy
• Grantee: Dimas Tadeu Covas
• Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC