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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Codon adaptation biases among sylvatic and urban genotypes of Dengue virus type 2

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Author(s):
Cunha, Marielton dos Passos [1] ; Ortiz-Baez, Ayda Susana [2, 1] ; de Melo Freire, Caio Cesar [3] ; de Andrade Zanotto, Paolo Marinho [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Biomed Sci Inst, Dept Microbiol, Lab Mol Evolut & Bioinformat, Sao Paulo - Brazil
[2] Inst Invest Recursos Biol Alexander von Humboldt, Bogota - Colombia
[3] UFSCar Fed Univ Sao Carlos, Dept Genet & Evolut, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: INFECTION GENETICS AND EVOLUTION; v. 64, p. 207-211, OCT 2018.
Web of Science Citations: 1
Abstract

Dengue virus (DENV) emerged from the sylvatic environment and colonized urban settings, being sustained in a human-Aedes-human transmission chain, mainly by the bites of females of the anthropophilic species Aedes aegypti. Herein, we sought evidence for fine-tuning in viral codon usage, possibly due to viral adaptation to human transmission. We compared the codon adaptation of DENV serotype 2 (DENV-2) genotypes from urban and sylvatic habitats and tried to correlate the findings with key evolutionary determinants. We found that DENV-2 codons of urban and sylvatic genotypes had a higher CAI to humans than to Ae. aegypti. Remarkably, we found no significant differences in codon adaptation to human between urban American/Asian and sylvatic DENV-2 genotypes. Moreover, CAI values were significantly different, when comparing all genotypes to Ae. aegypti codon preferences, with lower values for sylvatic than urban genotypes. In summary, our findings suggest the presence of a molecular signature among the genotypes that circulate in sylvatic and urban environments, and may help explain the trafficking of DENV-2 strains to an urban cycle. (AU)

FAPESP's process: 13/25434-3 - Intra-host genetic diversity of Dengue virus type 4 strains from the municipality of Guarujá, São Paulo
Grantee:Ayda Susana Ortiz Baez
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 16/08204-2 - Genetic and phylodynamics diversity of emerging and re-emerging arboviruses (DENV, ZIKV and CHIKV) in the Northeast and Southeast regions of Brazil, 2014-2016
Grantee:Marielton dos Passos Cunha
Support Opportunities: Scholarships in Brazil - Doctorate