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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fructose: Toxic effect on cardiorenal risk factors and redox state

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Author(s):
Francisqueti, Fabiane V. [1] ; Santos, Klinsmann C. [1] ; Ferron, Artur J. T. [1] ; Lo, Angelo T. C. [1] ; Minatel, Igor O. [1, 2] ; Campos, Dijon H. S. [1] ; Ferreira, Ana Lucia A. [1] ; Correa, Camila R. [1]
Total Authors: 8
Affiliation:
[1] State Univ Unesp, Med Sch, BR-18618000 Botucatu, SP - Brazil
[2] State Univ Unesp, Inst Biosci, Botucatu, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: SAGE OPEN MEDICINE; v. 4, JAN-DEC 2016.
Web of Science Citations: 3
Abstract

Aim: To investigate the effects of fructose consumption on the antioxidant capacity in heart and kidney, cardiovascular disease risk factors, and evaluation of these variables after its removal. Methods: Male Wistar rats (n = 36) were divided into control group (n = 12): standard chow + water or F group: standard chow + fructose in drinking water (30%) for 15 weeks. After, F group was divided to continue receiving standard chow + fructose in drinking water (30%) (n = 12) or standard chow + water (Ex group, n = 12) for 9 weeks. Water, chow and caloric diaries intake, final body weight, adiposity index, plasma glucose and triacylglycerol, systolic blood pressure, and cardiac and renal hydrophilic antioxidant capacity were analyzed. Results: Control and Ex groups consumed less chow and water compared to F group. Caloric intake was higher in control group. There was no difference in final body weight and adiposity index. Systolic blood pressure and cardiac and renal hydrophilic antioxidant capacity were worst in F group. Conclusion: Prolonged exposure to fructose induces oxidative stress, systolic blood pressure, and increase in triacylglycerol. When stopped fructose consumption, Ex group presented improvement in these variables, suggesting the toxicity effect of fructose when consumed in high amounts and prolonged exposure. (AU)

FAPESP's process: 15/10626-0 - Interrelation of gamma-oryzanol and activation of adipose R1 and R2 adipose receptors: possible effect on improvement of obesity-associated renal function
Grantee:Camila Renata Corrêa
Support Opportunities: Regular Research Grants