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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic Characterization of the Patois Serogroup (Genus Orthobunyavirus; Family Peribunyaviridae) and Evidence That Estero Real Virus is a Member of the Genus Orthonairovirus

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Author(s):
Aguilar, Patricia V. [1, 2, 3] ; de Souza, William Marciel [4] ; Silvas, Jesus A. [1, 2, 3] ; Wood, Thomas [5] ; Widen, Steven [5] ; Fumagalli, Marcilio Jorge [4] ; Teixeira Nunes, Marcio Roberto [6]
Total Authors: 7
Affiliation:
[1] Univ Texas Med Branch, Dept Pathol, 301 Univ Blvd, Galveston, TX 77555 - USA
[2] Inst Human Infect & Immun, Galveston, TX - USA
[3] Ctr Trop Dis, Galveston, TX - USA
[4] Univ Sao Paulo, Sch Med Ribeirao Preto, Virol Res Ctr, Sao Paulo - Brazil
[5] Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 - USA
[6] Inst Evandro Chagas, Ctr Technol Innovat, Ananindeua, Para - Brazil
Total Affiliations: 6
Document type: Journal article
Source: American Journal of Tropical Medicine and Hygiene; v. 99, n. 2, p. 451-457, 2018.
Web of Science Citations: 0
Abstract

Estero Real virus (ERV) was isolated in 1980 from Ornithodoros tadaridae ticks collected in El Estero Real, Sancti Spiritus, Cuba. Antigenic characterization of the isolate based on serological methods found a relationship with Abras and Zegla viruses and, consequently, the virus was classified taxonomically within the Patois serogroup. Given the fact that genetic characterization of Patois serogroup viruses has not yet been reported and that ERV is the only virus within the Patois serogroup isolated from ticks, we recently conducted nearly complete genome sequencing in an attempt to gain further insight into the genetic relationship of ERV with other Patois serogroup viruses and members of Peri-bunyaviridae family (Bunyavirales order). With the exception of ERV, our sequencing and phylogenetic studies revealed the close relationship of the Patois serogroup viruses to each other, forming a clear divergent clade from other members of the Orthobunyavirus genus (Peribunyaviridae family). Notably, our analysis also revealed that ERV forms a monophyletic clade that is closely related to species of the Orthonairovirus genus (Nairoviridae family) in all the genome segments. In light of these findings, we believe that the taxonomic classification of ERV should be revised. (AU)

FAPESP's process: 12/24150-9 - Research of virus in wild rodents, mosquitoes and ticks
Grantee:William Marciel de Souza
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/13981-0 - Characterization, genomics and diagnostic of viruses with importance for public health in Brazil by high throughput sequencing
Grantee:William Marciel de Souza
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/01414-1 - Production of recombinant viral antigenic peptides and development of methods for serological diagnosis of infections by Chikungunya, Mayaro and Zika viruses
Grantee:Marcilio Jorge Fumagalli
Support type: Scholarships in Brazil - Master