Terbinafine resistance conferred by multiple copies of the salicylate 1-monooxygenase gene in Trichophyton rubrum

Author(s)

Santos, Hemelin L. ^[1] ; Lang, Elza A. S. ^[1] ; Segato, Fernando ^{[1, 2]} ; Rossi, Antonio ^[1] ; Martinez-Rossi, Nilce M. ^[1]

Affiliation

^[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Genet, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Lorena Sch Engn, Dept Biotechnol, Sao Paulo - Brazil

• Document type: Journal article
• Source: Medical Mycology; v. 56, n. 3, p. 378-381, APR 2018.
• Web of Science Citations: 4

Abstract

Resistance to antifungals is a leading concern in the treatment of human mycoses. We demonstrate that the salA gene, encoding salicylate 1-monooxygenase, is involved in resistance of the dermatophyte Trichophyton rubrum to terbinafine, one of the most effective antifungal drugs against dermatophytes. A strain with multiple copies of salA was constructed and exhibited elevated expression of salA and increased terbinafine resistance. This reflects a mechanism not yet reported in a pathogenic fungus. (AU)

• FAPESP's process: 08/58634-7 - Functional and comparative genomics in fungi
• Grantee: Nilce Maria Martinez-Rossi
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/03847-7 - Molecular characterization of mechanisms involved in pathogenicity and cell signaling in fungi
• Grantee: Nilce Maria Martinez-Rossi
• Support Opportunities: Research Projects - Thematic Grants