| Full text | |
| Author(s): |
de Souza, Marcela M.
[1, 2]
;
Zerlotini, Adhemar
[3]
;
Geistlinger, Ludwig
[1]
;
Tizioto, Polyana C.
[4]
;
Taylor, Jeremy F.
[5]
;
Rocha, Marina I. P.
[2]
;
Diniz, Wellison J. S.
[2]
;
Coutinho, Luiz L.
[6]
;
Regitano, Luciana C. A.
[1]
Total Authors: 9
|
| Affiliation: | [1] Embrapa Pecuaria Sudeste, Anim Biotechnol, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Postgrad Program Evolutionary Genet & Mol Biol, BR-13560970 Sao Carlos, SP - Brazil
[3] Embrapa Informat Agropecuaria, Bioinformat Multiuser Lab, BR-70770901 Campinas, SP - Brazil
[4] NGS Genom Solut, Piracicaba, SP - Brazil
[5] Univ Missouri, Dept Anim Sci, Columbia, MO 65211 - USA
[6] Univ Sao Paulo, Funct Genom Ctr, BR-13418900 Piracicaba, SP - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 8, SEP 13 2018. |
| Web of Science Citations: | 2 |
| Abstract | |
Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a context-dependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species. (AU) | |
| FAPESP's process: | 12/23638-8 - Molecular basis of meat quality in Nelore beef cattle |
| Grantee: | Luciana Correia de Almeida Regitano |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 14/15183-6 - Identification and characterization of bovine transcription factor repertoire |
| Grantee: | Marcela Maria de Souza |
| Support type: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 12/20328-8 - Allelic expression in genes associated with meat tenderness in Nellore by transcriptomic analysis |
| Grantee: | Marcela Maria de Souza |
| Support type: | Scholarships in Brazil - Doctorate |