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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A comprehensive manually-curated compendium of bovine transcription factors

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Author(s):
de Souza, Marcela M. [1, 2] ; Zerlotini, Adhemar [3] ; Geistlinger, Ludwig [1] ; Tizioto, Polyana C. [4] ; Taylor, Jeremy F. [5] ; Rocha, Marina I. P. [2] ; Diniz, Wellison J. S. [2] ; Coutinho, Luiz L. [6] ; Regitano, Luciana C. A. [1]
Total Authors: 9
Affiliation:
[1] Embrapa Pecuaria Sudeste, Anim Biotechnol, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Postgrad Program Evolutionary Genet & Mol Biol, BR-13560970 Sao Carlos, SP - Brazil
[3] Embrapa Informat Agropecuaria, Bioinformat Multiuser Lab, BR-70770901 Campinas, SP - Brazil
[4] NGS Genom Solut, Piracicaba, SP - Brazil
[5] Univ Missouri, Dept Anim Sci, Columbia, MO 65211 - USA
[6] Univ Sao Paulo, Funct Genom Ctr, BR-13418900 Piracicaba, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, SEP 13 2018.
Web of Science Citations: 2
Abstract

Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a context-dependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species. (AU)

FAPESP's process: 12/23638-8 - Molecular basis of meat quality in Nelore beef cattle
Grantee:Luciana Correia de Almeida Regitano
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/15183-6 - Identification and characterization of bovine transcription factor repertoire
Grantee:Marcela Maria de Souza
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 12/20328-8 - Allelic expression in genes associated with meat tenderness in Nellore by transcriptomic analysis
Grantee:Marcela Maria de Souza
Support type: Scholarships in Brazil - Doctorate