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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Total syntheses of (+)-bernumidine and its unnatural enantiomer

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Author(s):
Correa, Bianca K. [1] ; Silva, Tamiris R. C. [1] ; Raminelli, Cristiano [1]
Total Authors: 3
Affiliation:
[1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Rua Prof Artur Riedel 275, BR-09972270 Diadema, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Clinica Chimica Acta; v. 485, p. 3583-3585, OCT 2018.
Web of Science Citations: 0
Abstract

Total syntheses of (+)-bernumidine and its unnatural enantiomer were accomplished through chemoenzymatic dynamic kinetic resolution and ruthenium(II)-catalyzed enantioselective hydrogenation, which provided (R)-salsolidine propyl carbamate and N-acetyl (S)-salsolidine in high yields and enantiomeric excesses, respectively. Both enantiomers of salsolidine were accessed and converted into (+)- and (-)-bernumidine via simple and efficient transformations. (C) 2018 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 17/21990-0 - 2-(Trialkylsilyl)aryl trifluoromethanesulfonates as aryne precursors in the development of methodologies for obtaining nitrogen-containing heterocyclic compounds and total syntheses of bioactive natural products
Grantee:Cristiano Raminelli
Support type: Regular Research Grants