Burden of cancer attributable to lifestyle risk factors in Brazil
| Full text | |
| Author(s): |
Machado de Rezende, Leandro Fornias
[1]
;
Totaro Garcia, Leandro Martin
[2]
;
Mielke, Gregore Iven
[3, 4]
;
Lee, Dong Hoon
[5]
;
Wu, Kana
[5]
;
Giovannucci, Edward
[6, 7, 5, 8]
;
Eluf-Neto, Jose
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Fac Med FMUSP, Dept Med Prevent, Sao Paulo, SP - Brazil
[2] Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, UKCRC Ctr Diet & Act Res, Cambridge - England
[3] Univ Fed Pelotas, Postgrad Program Epidemiol, Pelotas, RS - Brazil
[4] Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld - Australia
[5] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA - USA
[6] Harvard Med Sch, Boston, MA - USA
[7] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA - USA
[8] Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 - USA
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | CANCER EPIDEMIOLOGY; v. 56, p. 38-45, OCT 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
Background: Physical activity is associated with lower risk of colon and breast cancers. Herein we estimated preventable fractions of colon and breast cancers in Brazil by increasing population-wide physical activity to different counterfactual scenarios. Methods: We used data from a representative national survey in Brazil and corresponding relative risks of colon and postmenopausal breast cancers from a meta-analysis. Estimated cancer incidence was retrieved from GLOBOCAN and Brazilian National Cancer Institute. Five counterfactual scenarios for physical activity were considered: (i) theoretical minimum risk exposure level (>= 8,000 metabolic equivalent of tasks-minute/week-MET-min/week); (ii) physical activity recommendation (>= 600 MET-min/week); (iii) a 10% reduction in prevalence of insufficient physical inactivity (< 600 MET-min/week); (iv) physical activity level in each state equals the most active state in Brazil; (v) closing the gender differences in physical activity. Results: About 19% (3,630 cases) of colon cancers and 12% (6,712 cases) of postmenopausal breast cancers could be prevented by increasing physical activity to >= 8,000 MET-min/week. Plausible counterfactual scenarios suggested the following impact on cancer prevention: reaching physical activity recommendation: 1.7% (1,113 cases) of breast and 6% (1,137 cases) of colon; 10% reduction in physical inactivity prevalence: 0.2% (111 cases) of breast and 0.6% (114 cases) of colon; most active state scenario: 0.3% (168 cases) of breast and 1% (189 cases) of colon; reducing gender differences in physical activity: 1.1% (384 cases) of breast and 0.6% (122 cases) of colon. Conclusions: High levels of physical activity are required to achieve a sizable impact on breast and colon cancer prevention in Brazil. (AU) | |
| FAPESP's process: | 16/21390-0 - Burden of cancer attributable to lifestyle risk factors in Brazil |
| Grantee: | Leandro Fórnias Machado de Rezende |
| Support type: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 14/25614-4 - Physical inactivity and cancer: from evaluation of etiological evidence to public health impact |
| Grantee: | Leandro Fórnias Machado de Rezende |
| Support type: | Scholarships in Brazil - Doctorate |