Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neural stem cell differentiation into mature neurons: Mechanisms of regulation and biotechnological applications

Full text
Author(s):
Vieira, Mariana S. [1, 2] ; Santos, Anderson K. [1] ; Vasconcellos, Rebecca [1, 2] ; Goulart, Vania A. M. [1] ; Parreira, Ricardo C. [1, 2] ; Kihara, Alexandre H. [3] ; Ulrich, Henning [4] ; Resende, Rodrigo R. [1, 2]
Total Authors: 8
Affiliation:
[1] Univ Fed Minas Gerais, Inst Ciencia Biol, Dept Bioquim & Imunol, Belo Horizonte, MG - Brazil
[2] Inst Nanocell, Divinopolis, MG - Brazil
[3] Univ Fed ABC, Ctr Matemat Comput & Cognicao, Sao Bernardo Do Campo, SP - Brazil
[4] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Review article
Source: BIOTECHNOLOGY ADVANCES; v. 36, n. 7, p. 1946-1970, NOV 15 2018.
Web of Science Citations: 9
Abstract

The abilities of stern cells to self-renew and form different mature cells expand the possibilities of applications in cell based therapies such as tissue recomposition in regenerative medicine, drug screening, and treatment of neurodegenerative diseases. In addition to stem cells found in the embryo, various adult organs and tissues have niches of stem cells in an undifferentiated state. In the central nervous system of adult mammals, neurogenesis occurs in two regions: the subventricular zone and the dentate gyros in the hippocampus. The generation of the different neural lines originates in adult neural stem cells that can self-renew or differentiate into astrocytes, oligodendrocytes, or neurons in response to specific stimuli. The regulation of the fate of neural stem cells is a finely controlled process relying on a complex regulatory network that extends from the epigenetic to the translational level and involves extracellular matrix components. Thus, a better understanding of the mechanisms underlying how the process of neurogenesis is induced, regulated, and maintained will provide elues for development of novel for strategies for neurodegenerative therapies. In this review, we focus on describing the mechanisms underlying the regulation of the neuronal differentiation process by transcription factors, microRNAs, and extracellular matrix components. (AU)

FAPESP's process: 12/50880-4 - Stem cells: from basic studies of kinin and purinergic receptor roles towards therapeutical applications
Grantee:Alexander Henning Ulrich
Support Opportunities: Research Projects - Thematic Grants