Development of bioconjugates containing peptides for combined therapy aimed the tr...
| Full text | |
| Author(s): |
Batista, Mariana Nogueira
[1]
;
da Silva Sanches, Paulo Ricardo
[2]
;
Carneiro, Bruno Moreira
[1]
;
Silva Braga, Ana Claudia
[1]
;
Fernandes Campos, Guilherme Rodrigues
[1]
;
Chilli, Eduardo Maffud
[2]
;
Rahal, Paula
[1]
Total Authors: 7
|
| Affiliation: | [1] UNESP Sao Paulo State Univ, Inst Biosci Language & Exact Sci, Sao Jose Do Rio Preto, SP - Brazil
[2] UNESP Sao Paulo State Univ, Inst Chem, Araraquara, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 8, SEP 25 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
In recent years, synthetic peptides have been considered promising targets for drug development that possess low side-effects, are cost-effective and are susceptible to rational design. Hecate was initially described as a potent bacterial inhibitor and subsequently as an anticancer drug with functions related to its lipid interaction property. Viruses, such as hepatitis C virus (HCV), have a lipid-dependent life cycle and could be affected by Hecate in many ways. Here, we assessed modifications on Hecate's N-terminus region and its effects on HCV and hepatotoxicity. Gallic acid-conjugated Hecate was the most efficient Hecate-derivative, presenting high potential as an antiviral and inhibiting between 50 to 99% of all major steps within the HCV infectious cycle. However, the most promising aspect was GA-Hecate's mechanism of action, which was associated with a balanced lipid interaction with the viral envelope and lipid droplets, as well as dsRNA intercalation, allowing for the possibility to affect other ssRNA viruses and those with a lipid-dependent cycle. (AU) | |
| FAPESP's process: | 17/00287-9 - Adaptation of a rat derived HCV-RELATED rodent Hepacivirus to the mouse host |
| Grantee: | Mariana Nogueira Batista |
| Support type: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 15/23244-8 - Development of multifunctional prodrugs for combination therapy against hepatocellular carcinoma and HCV |
| Grantee: | Paulo Ricardo da Silva Sanches |
| Support type: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery |
| Grantee: | Glaucius Oliva |
| Support type: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 16/02174-4 - Assessment of synthetic peptides on directed Hepatitis C Virus inhibition |
| Grantee: | Mariana Nogueira Batista |
| Support type: | Scholarships in Brazil - Doctorate |