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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Orexinergic neurons are involved in the chemosensory control of breathing during the dark phase in a Parkinson's disease model

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Author(s):
Oliveira, Luiz M. [1] ; Falquetto, Barbara [1] ; Moreira, Thiago S. [2] ; Takakura, Ana C. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, 1524 Lineu Prestes Ave, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Experimental Neurology; v. 309, p. 107-118, NOV 2018.
Web of Science Citations: 2
Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra compacta (SNpc) and the only risk factor is aging. We showed that in 6-hydroxydopamine (6-OHDA)-model of PD there is a reduction in the neuronal profile within the brainstem ventral respiratory column with a decrease in the hypercapnic ventilatory response. Here we tested the involvement of orexin cells from the lateral hypothalamus/perifornical area (LH/PeF) on breathing in a 6-OHDA PD model. In this model of PD, there is a reduction in the total number of orexinergic neurons and in the number of orexinergic neurons that project to the RTN, without changing the number of CO2-activated orexinergic neurons during the dark phase. The ventilation at rest and in response to hypercapnia (7% CO2) was assessed in animals that received 6-OHDA or vehicle injections into the striatum and saporin anti-Orexin-B or IgG saporin into the LH/PeF during the sleep and awake states. The experiments showed a reduction of respiratory frequency (f(R)) at rest during the light phase in PD animals only during sleep. During the dark phase, there was an impaired f(R) response to hypercapnia in PD animals with depletion of orexinergic neurons in awake and sleeping rats. In conclusion, the degeneration of orexinergic neurons in this model of PD can be related to impaired chemoreceptor function in the dark phase. (AU)

FAPESP's process: 16/23281-3 - Encephalic regions responsible for neuroplasticity observed in respiratory response induced by hypercapnia in a modelo of Parkinson's Disease
Grantee:Ana Carolina Takakura Moreira
Support Opportunities: Regular Research Grants
FAPESP's process: 16/22069-0 - Amelioration of the brainstem vascular imbalances in an spontaneously hypertensive rats with exercise
Grantee:Thiago dos Santos Moreira
Support Opportunities: Regular Research Grants
FAPESP's process: 17/12266-6 - Optogenetic stimulation of pre-Bötzinger complex neurons and the control of breathing in a mice model of Parkinson's disease
Grantee:Luiz Marcelo Oliveira Santos
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 15/23376-1 - Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity
Grantee:Thiago dos Santos Moreira
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 15/18842-3 - Orexinergic and aminergic mechanisms in respiratory control in an animal model of Parkinsons Disease
Grantee:Luiz Marcelo Oliveira Santos
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/11268-0 - Mechanisms involved in medullary neurodegeneration in Parkinson's Disease
Grantee:Bárbara Falquetto
Support Opportunities: Scholarships in Brazil - Post-Doctoral