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Role of adenosine and A1 receptors in the lateral hypothalamus and perifornical area (LHA / PFA) in daily variations of the hypercapnic ventilatory response

Grant number: 17/02181-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2017
Effective date (End): December 31, 2017
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal Investigator:Mirela Barros Dias
Grantee:Laísa Taís Cabral Rodrigues Xavier
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated research grant:13/04216-8 - Neural mechanisms involved in the diurnal variation of the central chemoreflex control, AP.JP


Evidence suggests the existence of daily variations in control of the central chemoreflex, and a series of studies have attributed to orexinergic neurons of lateral hypothalamus and perifornical area (LH/PFA) the role of circadian modulator of the central chemosensitivity, but the mechanisms involved have not been elucidated so far. This project aims to investigate the possible role of adenosine and A1 receptors in LH/PFA in the modulation of the ventilatory response to hypercapnia in different phases of the sleep-wake and light-dark cycle. Experiments will be performed on unanesthetized Wistar rats in a whole body plethysmograph system, together with EEG and EMG recordings, submitted to microinjections of the A1 receptor antagonist, DPCPX, and its vehicle in the LH/PFA. The effects of these approaches will be studied in ventilation in air and 7% CO2 hypercapnia, during sleep and wakefulness, in the light and the dark periods of the light-dark cycle. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CABRAL RODRIGUES, LAISA TAIS; SALATA, BRUNO; HORTA-JUNIOR, JOSE DE ANCHIETA C.; GARGAGLIONI, LUCIANE H.; DIAS, MIRELA BARROS. Adenosine in the lateral hypothalamus/perifornical area does not participate on the CO2 chemoreflex. Respiratory Physiology & Neurobiology, v. 276, . (16/13136-6, 17/02181-3, 13/04216-8)

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