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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of mesenchymal stromal cells on type 1 diabetes mellitus rat muscles

Full text
Author(s):
Luna, Genoveva Flores [3]
Total Authors: 1
Affiliation:
[1] Univ Fed Sao Carlos, Dept Med, Rodovia Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: MUSCLE & NERVE; v. 58, n. 4, p. 583-591, OCT 2018.
Web of Science Citations: 1
Abstract

Introduction: Type 1 diabetes mellitus (DM) causes marked skeletal muscle atrophy. Mesenchymal stromal cells (MSC) are an attractive therapy to avoid diabetic complications because of their ability to modify the microenvironment at sites of tissue injury. The objective of this study was to evaluate the effects of MSC transplantation on muscle adaptation caused by diabetes. Methods: DM was induced by streptozotocin (STZ), and the diabetic animals received systemic MSC transplantation. The von Frey test and footprint analysis were used to assess sensation and sensory motor performance, respectively. Tibialis anterior muscles were investigated by morphology; molecular markers atrogin-1/muscle RING-finger protein-1, nuclear factor B/p38 mitogen-activated protein kinase, tumor necrosis-like weak inducer of apoptosis/fibroblast growth factor-inducible 14, myostatin, myogenic differentiation 1, and insulin-like growth factor 1 were also assessed. Results: MSC transplantation improved sensation and walking performance and also decreased muscle fibrosis in DM rats by modulating atrogenes but did not prevent muscle atrophy. Discussion: MSCs can reduce muscle and functional complications that result from type 1 DM in rats. Muscle Nerve58: 583-591, 2018 (AU)

FAPESP's process: 12/51783-2 - Effects of mesenchymal stem cells infusion on neuromuscular system in a model of diabetic neuropathy
Grantee:Ângela Merice de Oliveira Leal
Support Opportunities: Regular Research Grants
FAPESP's process: 13/21621-3 - Effect of task specific training on muscle adaptation in gerbils post-ischemic stroke
Grantee:Thiago Luiz de Russo
Support Opportunities: Regular Research Grants