Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chronotropic Incompetence and Reduced Heart Rate Recovery in Rheumatoid Arthritis

Full text
Pecanha, Tiago ; Rodrigues, Reynaldo ; Pinto, Ana Jessica ; Sa-Pinto, Ana Lucia ; Guedes, Lissiane ; Bonfiglioli, Karina ; Gualano, Bruno ; Roschel, Hamilton
Total Authors: 8
Document type: Journal article
Source: JCR-JOURNAL OF CLINICAL RHEUMATOLOGY; v. 24, n. 7, p. 375-380, OCT 2018.
Web of Science Citations: 0

Background/Objective Recent studies have indicated that cardiac autonomic dysfunction is an early sign of cardiovascular impairment in rheumatoid arthritis (RA). Previous studies have mainly focused on resting assessments; however, analysis of heart rate (HR) responses to exercise might provide additional information on cardiac autonomic dysfunction in this disease. Thus, we aimed to assess the HR responses during and after a maximal graded exercise test in patients with RA and healthy controls (CONs). Methods This was a cross-sectional study in which 27 female RA patients and 14 female CONs frequency matched by physical activity, age, and body mass index were compared for HR responses during and after a maximal graded exercise test. Results Rheumatoid arthritis patients showed reduced chronotropic response (94.3% 16.3% vs. 106.1% +/- 10.3%, p = 0.02) and lower HR recovery (HRR) at 30 seconds (8.6 +/- 6.7 vs. 13.4 +/- 5.2 beats/min {[}bpm], p = 0.02), 60 seconds (16.5 +/- 7.8 vs. 24.0 +/- 9.9 bpm, p = 0.01), 120 seconds (32.6 +/- 9.9 vs. 40.7 +/- 12.3 bpm, p = 0.03), and 180 seconds (46.5 +/- 12.6 vs. 55.5 +/- 13.4 bpm, p = 0.05) post-maximal exercise test when compared with CONs. Moreover, the prevalence of chronotropic incompetence (i.e., failure to reach 80% of the HR-predicted response) and abnormal HRR (i.e., HRR 12 bpm) were, respectively, 22.2% and 37.1% in RA patients. Conclusions Patients with RA showed reduced chronotropic response to exercise and slower postexercise HRR. These abnormal autonomic responses to exercise indicate the presence of cardiac autonomic dysfunction and increased cardiovascular risk in this population. (AU)

FAPESP's process: 15/26937-4 - Studies on physical (in)activity in patients with rheumatoid arthritis: characterization, associations with disease and effects of breaking up sedentary time
Grantee:Ana Jéssica Pinto
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 16/23319-0 - Cardiovascular autonomic dysfunction in rheumatoid arthritis patients: characterization, associations with the disease and effects of breaks in sedentary time
Grantee:Tiago Peçanha de Oliveira
Support type: Scholarships in Brazil - Post-Doctorate