Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Permeability of DOPC bilayers under photoinduced oxidation: Sensitivity to photosensitizer

Full text
Bacellar, Isabel O. L. [1, 2] ; Baptista, Mauricio S. [1] ; Junqueira, Helena C. [1] ; Wainwright, Mark [3] ; Thalmann, Fabrice [2] ; Marques, Carlos M. [2] ; Schroder, Andre P. [2]
Total Authors: 7
[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo - Brazil
[2] Univ Strasbourg, Inst Charles Sadron, CNRS, UP22, 23 Rue Loess, F-67200 Strasbourg - France
[3] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Liverpool L3 3AF, Merseyside - England
Total Affiliations: 3
Document type: Journal article
Source: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES; v. 1860, n. 11, p. 2366-2373, NOV 2018.
Web of Science Citations: 5

The modification of lipid bilayer permeability is one of the most striking yet poorly understood physical transformations that follow photoinduced lipid oxidation. We have recently proposed that the increase of permeability of photooxidized 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) bilayers is controlled by the time required by the oxidized lipid species to diffuse and aggregate into pores. Here we further probe this mechanism by studying photosensitization of DOPC membranes by methylene blue (MB) and DO15, a more hydrophobic phenothiazinium photosensitizer, under different irradiation powers. Our results not only reveal the interplay between the production rate and the diffusion of the oxidized lipids, but highlight also the importance of photosensitizer localization in the kinetics of oxidized membrane permeability. (AU)

FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 13/11640-0 - Relationship between the photoinduced damage in lipids and membrane permeabilization
Grantee:Isabel de Oliveira Lima Bacellar
Support type: Scholarships in Brazil - Doctorate (Direct)