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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The redox balance of healthy Brazilian adults is associated with GPX1 Pro198Leu and-602A/G polymorphisms, selenium status, and anthropometric and lifestyle parameters

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Author(s):
Almondes, Kaluce G. S. [1] ; Cardoso, Barbara R. [2, 3, 4] ; Cominetti, Cristiane [5] ; Nogueira, Nadir N. [6] ; Marreiro, Dilina N. [6] ; Oliveira, Tiago F. [7] ; Loureiro, Ana P. M. [8] ; Cozzolino, Silvia M. F. [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, Av Prof Lineu Prestes 580, Bloco 14, Sao Paulo, SP - Brazil
[2] Deakin Univ, IPAN, Sch Exercise & Nutr Sci, Geelong, Vic - Australia
[3] Florey Inst Neurosci & Mental Hlth, Melbourne Dementia Res Ctr, Parkville, Vic - Australia
[4] Univ Melbourne, Parkville, Vic - Australia
[5] Univ Fed Goias, Fac Nutr, Nutr Genom Res Grp, Rua 227 S-N, Quadra 68, Goiania, Go - Brazil
[6] Univ Fed Piaui, Dept Nutr, Univ Campus Ministro Petronio Portella, Teresina, PI - Brazil
[7] Fed Univ Hlth Sci Porto Alegre, Pharmacosci Dept, Ctr Hist, Av Sarmento Leite 245, Porto Alegre, RS - Brazil
[8] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, Av Prof Lineu Prestes 580, Bloco 13B, Sao Paulo, SP - Brazil
Total Affiliations: 8
Document type: Journal article
Source: FOOD & FUNCTION; v. 9, n. 10, p. 5313-5322, OCT 1 2018.
Web of Science Citations: 0
Abstract

Purpose: Considering that oxidative stress is implicated in the pathogenesis and progression of different health conditions, we aimed to evaluate whether the redox balance of a healthy Brazilian population is associated with GPX1 polymorphisms, selenium status, lipid profile, and anthropometric and lifestyle parameters. Methods: 343 healthy adults were assessed for redox balance markers {[}glutathione peroxidase (GPx) and superoxide dismutase (SOD) activity; malondialdehyde (MDA) and oxygen radical absorption capacity (ORAC)]; genotyped for the polymorphisms GPX1 Pro198Leu (rs1050450), -602A/G (rs3811699) and Arg5Pro (rs8179169); evaluated for selenium biomarkers (plasma, erythrocyte, and urine) and intake; and assessed for lipid profile. Anthropometric (BMI) and lifestyle data (physical activity, current smoking habit and alcohol consumption) were collected. Multivariable regression models were applied to investigate the possible associations. Results: Although there were no differences in GPx activity according to GPX1 Pro198Leu and -602A/G polymorphisms, this redox balance marker was positively associated with erythrocyte selenium and negatively associated with the presence of a minor allele of Pro198Leu. SOD activity was positively associated with the presence of a minor allele for these polymorphisms. ORAC showed the same pattern among Leu and G carriers and was positively associated with Leu allele presence, BMI and alcohol intake. MDA was only associated negatively with the male sex and plasma selenium. Conclusions: Our findings suggest that the redox balance of a Brazilian healthy population is associated with GPX1 polymorphisms (Pro198Leu and -602A/G), selenium status, BMI, sex, smoking habit and alcohol consumption. (AU)

FAPESP's process: 12/24762-4 - Determination of zinc status in preschool children and its relation to the zinc carriers genes expression
Grantee:Silvia Maria Franciscato Cozzolino
Support Opportunities: Regular Research Grants