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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Alendronate release from calcium phosphate cement for bone regeneration in osteoporotic conditions

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van Houdt, Claire I. A. [1, 2] ; Gabbai-Armelin, Paulo R. [3, 4] ; Lopez-Perez, Paula M. [1] ; Ulrich, Dietmar J. O. [2] ; Jansen, John A. [1] ; Renno, Ana Claudia M. [3, 4] ; van den Beucken, Jeroen J. J. P. [1]
Total Authors: 7
[1] Radboudumc, Dept Regenerat Biomat, Nijmegen - Netherlands
[2] Radboudumc, Dept Plast Reconstruct & Hand Surg, Nijmegen - Netherlands
[3] Fed Univ Sao Paulo UNIFESP, Dept Biosci, Lab Biomat & Tissue Engn, Sao Paulo - Brazil
[4] Fed Univ Sao Carlos UFSCar, Dept Physiotherapy, Biotechnol Postgrad Program, Sao Carlos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, OCT 18 2018.
Web of Science Citations: 1

Osteoporosis represents a major health problem in terms of compromising bone strength and increasing the risk of bone fractures. It can be medically treated with bisphosphonates, which act systemically upon oral or venous administration. Further, bone regenerative treatments in osteoporotic conditions present a challenge. Here, we focused on the development of a synthetic bone substitute material with local diminishing effects on osteoporosis. Composites were created using calcium phosphate cement (CPC; 60 wt%) and polylactic-co-glycolic acid (PLGA; 40 wt%), which were loaded with alendronate (ALN). In vitro results showed that ALN-loaded CPC/PLGA composites presented clinically suitable properties, including setting times, appropriate compressive strength, and controlled release of ALN, the latter being dependent on composite degradation. Using a rat femoral condyle bone defect model in osteoporotic animals, ALN-loaded CPC/PLGA composites demonstrated stimulatory effects on bone formation both within and outside the defect region. (AU)

FAPESP's process: 15/20704-8 - Performance of bioglass/collagen/magnesium composites in bone repair of rats
Grantee:Paulo Roberto Gabbai Armelin
Support type: Scholarships in Brazil - Post-Doctorate