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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Can Genetic Factors Compromise the Success of Dental Implants? A Systematic Review and Meta-Analysis

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Author(s):
Santiago Junior, Joel Ferreira [1] ; Biguetti, Claudia Cristina [2] ; Matsumoto, Mariza Akemi [2] ; Kudo, Guilherme Abu Halawa [1] ; Parra da Silva, Raquel Barroso [2] ; Saraiva, Patricia Pinto [1] ; Fakhouri, Walid D. [3, 4]
Total Authors: 7
Affiliation:
[1] Univ Sagrado Coracao, Proreitoria Pesquisa & Posgrad PRPPG, 10-50 Irma Arminda, BR-17011160 Bauru, SP - Brazil
[2] Sao Paulo State Univ Unesp, Sch Dent, Dept Basic Sci, BR-16015050 Aracatuba, SP - Brazil
[3] Univ Texas Hlth Sci Ctr Houston, Ctr Craniofacial Res, Dept Diagnost & Biomed Sci, Sch Dent, Houston, TX 77054 - USA
[4] Univ Texas Hlth Sci Ctr Houston, Dept Pediat, McGovern Med Sch, Houston, TX 77030 - USA
Total Affiliations: 4
Document type: Review article
Source: GENES; v. 9, n. 9 SEP 2018.
Web of Science Citations: 1
Abstract

Dental implants provide a predictable treatment option for partial and complete edentulism via the placement of a fixed permanent artificial root to support prosthetic dental crowns. Despite the high survival rates, long-term dental implant failures are still reported, leading to implant removals and additional financial and health burdens. While extrinsic factors that improve the success rate of implants have been well explored, the impact of genetic factors on this matter is poorly understood. A systematic review and meta-analysis study was conducted to determine whether genetic factors contribute to an increased risk of dental implant failures. A comprehensive search for peer-reviewed articles on dental implants and genetic factors was performed using various literature database libraries. The study design was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, and the obtained records were registered in the International Prospective Register of Systematic Reviews (PROSPERO) database. According to the exclusion/inclusion criteria, 13 studies were eligible for this study out of 809 articles. The meta-analysis of the combined association studies of DNA variations and dental implants did not indicate an increased risk for implant failure due to DNA variations in IL-1B, IL-10 and TNF-alpha. This study emphasizes the need for larger randomized controlled clinical trials to inform clinicians and patients about the role of genetic factors on dental implant survival and the success rate in healthy and compromised patients. (AU)

FAPESP's process: 15/20827-2 - Effect of bone quality and connection type of dental implants on stress distribution
Grantee:Joel Ferreira Santiago Junior
Support Opportunities: Regular Research Grants