High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individuals

Author(s)

Spada, Tania C. ^{[1, 2, 3]} ; Silva, Jose M. R. D. ^[4] ; Francisco, Lucila S. ^[5] ; Marcal, Lia J. ^{[6, 7]} ; Antonangelo, Leila ^{[6, 7]} ; Zanetta, Dirce M. T. ^[8] ; Yu, Luis ^{[1, 2, 3]} ; Burdmann, Emmanuel A. ^{[1, 2, 3]}

Affiliation

^[1] Hosp Clin Sao Paulo, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Med Sch, Div Nephrol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Med Sch, LIM 12, Sao Paulo - Brazil

^[4] Sao Paulo State Univ, Sch Sci, Bauru - Brazil

^[5] Univ Guarulhos, Div Sports, Guarulhos - Brazil

^[6] Univ Sao Paulo, Med Sch, Hosp Clin, Dept Pathol, Clin Lab, Sao Paulo - Brazil

^[7] Univ Sao Paulo, Med Sch, Hosp Clin, LIM 3, Sao Paulo - Brazil

^[8] Univ Sao Paulo, Sch Publ Hlth, Sao Paulo - Brazil

• Document type: Journal article
• Source: PLoS One; v. 13, n. 11 NOV 6 2018.
• Web of Science Citations: 3

Abstract

Purpose High-intensity interval resistance training (HIIRT) is an increasingly popular exercise program that provides positive results with short sessions. This study aimed to evaluate whether an HIIRT session causes muscle and kidney damage. Methods Fifty-eight healthy volunteers (median age 24 years, 50% women) participated in this study and performed a HIIRT session. The Borg CR10 scale for pain (CR1OP) and blood and urine samples were collected before (baseline) and 2 and 24 hours after the HIIRT session. Blood samples were analyzed for serum creatinine (SCr), creatine kinase (CK) and myoglobin. Urine samples were assessed for creatinine, neutrophil gelatinase-associated lipocalin, interleukin 18, calbindin, microalbuminuria, trefoil factor-3 and beta-2 microglobulin. Results CR10P had a significant increase at 2 and 24 hours post-workout, and CK increased significantly at 2 hours and increased further at 24 hours. Myoglobin increased significantly at 2 hours and remained elevated at 24 hours. SCr increased modestly but significantly at 24 hours only in men. Three men met the KDIGO diagnostic criteria for acute kidney injury. The urinary kidney injury biomarkers increased significantly at 2 hours and returned to the baseline values 24 hours after HIIRT. Conclusions A single HIIRT session caused early and significant elevations in CK, myoglobin, SCr, microalbuminuria and urinary biomarkers indicative of kidney tubular injury, suggesting the occurrence of muscle and kidney damage. (AU)

• FAPESP's process: 14/19286-4 - Individuals with high risk for acute kidney injury development in clinical relevant situations: a prospective study on epidemiological, diagnostic and prognostic aspects
• Grantee: Emmanuel de Almeida Burdmann
• Support Opportunities: Research Projects - Thematic Grants