Effects of resistance exercise training in mechanisms cellular stress response and in the process of autophagy in experimental chronic kidney disease

• Grant number: 12/15789-6
• Support type: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): January 01, 2013
• Effective date (End): December 31, 2013
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Niels Olsen Saraiva Câmara
• Grantee: Débora Tavares de Resende e Silva Abate
• Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 12/02270-2 - New cellular, molecular and immunological mechanisms involved in acute and chronic renal injury: the search for new therapeutical approaches, AP.TEM

Abstract

Chronic kidney disease (CKD), regardless of the initial injury is associated with damage to the tubulointerstitial compartment, including tubular degeneration, interstitial infiltration and fibrosis, which leads to the progressive decline in renal function. In an attempt to minimize the damage caused by the DRC, there are cytoprotective mechanisms that limit injuries and of these mechanisms, we can highlight: the induction of expression of heme oxygenase-1 (HO1), which promotes the formation of anti-apoptotic and immunomodulatory effects, the endoplasmic reticulum stress, which involves the participation of proteins essential for the maintenance of cellular homeostasis and autophagy. It is reported that patients with CKD often have a decreased physical performance, and despite evidence that the practice of exercise is safe and beneficial in patients with CKD is still resistance in their practice. Patients with CKD often have weak muscles and exercise training, can benefit from strength training interventions. Moreover, recent reviews have described the practice of physical exercise has anti-inflammatory effects, which focused on three possible mechanisms: the reduction of visceral fat mass, increased production and release of inflammatory cytokines, and reduced expression of Toll-like receptors (TLRs). Therefore, we will seek to further information on the influence of resistance exercise in DRC in response to cellular stress in renal injury, because in addition to providing information on responses to exercise practice, will provide new therapeutic targets that may restore homeostasis cell and therefore reduces the lesions generated by the DRC, and benefit the quality of life of patients with CKD.