| Full text | |
| Author(s): |
Oliva, Azahara
[1, 2]
;
Fernandez-Ruiz, Antonio
[1]
;
de Oliveira, Eliezyer Fermino
[1, 3]
;
Buzsaki, Gyorgy
[1, 4]
Total Authors: 4
|
| Affiliation: | [1] NYU, Neurosci Inst, New York, NY 10016 - USA
[2] Columbia Univ, Zuckerman Mind Brain Behav Inst, Dept Neurosci, New York, NY 10027 - USA
[3] Univ Fed ABC, Ctr Math Comp & Cognit, Sao Bernardo Do Campo, SP - Brazil
[4] NYU, Ctr Neural Sci, New York, NY 10016 - USA
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | CELL REPORTS; v. 25, n. 7, p. 1693+, NOV 13 2018. |
| Web of Science Citations: | 6 |
| Abstract | |
Hippocampal sharp-wave ripples (SPW-Rs) support consolidation of recently acquired episodic memories and planning future actions by generating ordered neuronal sequences of previous or future experiences. SPW-Rs are characterized by several spectral components: a slow (5-15 Hz) sharp-wave, a high-frequency ``ripple{''} oscillation (150-200 Hz), and a slow ``gamma{''} oscillation (20-40 Hz). Using laminar hippocampal recordings and optogenetic manipulations, we dissected the origin of these spectral components. We show that increased power in the 20-40 Hz band does not reflect an entrainment of CA1 and CA3 neurons at gamma frequency but the power envelope of overlapping ripples. Spike-local field potential coupling between unit firing in CA1 and CA3 regions during SPW-Rs is lowest in the gamma band. Longer SPW-Rs are preceded by increased firing in the entorhinal cortex. Thus, fusion of SPW-Rs leads to lengthening of their duration associated with increased power in the slow gamma band without the presence of true oscillation. (AU) | |
| FAPESP's process: | 17/03729-2 - Investigating the neural substrates of temporal task learning |
| Grantee: | Eliezyer Fermino de Oliveira |
| Support Opportunities: | Scholarships abroad - Research Internship - Master's degree |