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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Beneficial effects of ascorbic acid to treat lung fibrosis induced by paraquat

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Author(s):
da Silva, Marcia Rodrigues [1] ; Schapochnik, Adriana [1] ; Leal, Mayara Peres [1] ; Esteves, Janete [1] ; Hebeda, Cristina Bichels [1] ; Sandri, Silvana [2] ; Pavani, Christiane [1] ; Ratto Tempestini Horliana, Anna Carolina [1] ; Farsky, Sandra H. P. [2] ; Lino-dos-Santos-Franco, Adriana [1]
Total Authors: 10
Affiliation:
[1] Univ Nove de Julho UNINOVE, Post Grad Program Biophoton Appl Hlth Sci, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PLoS One; v. 13, n. 11 NOV 5 2018.
Web of Science Citations: 2
Abstract

Paraquat (PQ) is one of the most widely employed herbicides that is used worldwide and it causes severe toxic effects in humans and animals. A PQ exposition can lead to pulmonary fibrosis (PF) and the mechanisms seem to be linked to oxidative stress, although other pathways have been suggested. Antioxidants can be useful as a therapy, although interventions with this kind of system are still controversial. Hence, this study has investigated the role of ascorbic acid (vitamin C) post-treatment on PQ-induced PF in male C57/BL6 mice. Pulmonary fibrosis was induced by a single PQ injection (10mg/kg; i.p.). The control group received a PQ vehicle. Seven days after the PQ or vehicle injections, the mice received vitamin C (150 mg/kg, ip, once a day) or the vehicle, over the following 7 days. Twenty-four hours after the last dose of vitamin C or the vehicle, the mice were euthanized and their bronchoalveolar lavage fluid (BALF) and their lungs were collected. The data obtained showed that vitamin C reduced the cellular recruitment, the secretion of IL-17 -a cytokine involved in neutrophils migration, TGF-beta-a pro-fibrotic mediator and the collagen deposition. Moreover, vitamin C elevated the superoxide dismutase (SOD) and catalase levels, both antioxidant enzymes, but it did not alter the tracheal contractile response that was evoked by methacholine. Therefore, the researchers have highlighted the mechanisms of vitamin C as being non-invasive and have suggested it as a promising tool to treat lung fibrosis when it is induced by a PQ intoxication. (AU)

FAPESP's process: 17/06444-9 - Evaluation of LED treatment in the resolution of acute lung injury induced by sepsis
Grantee:Adriana Lino dos Santos Franco
Support type: Regular Research Grants