Nonfunctioning Pituitary Adenoma Recurrence and Its Relationship with Sex, Size, and Hormonal Immunohistochemical Profile

Author(s)

Batista, Rafael Loch ^[1] ; Trarbach, Ericka Barbosa ^[2] ; Marques, Mateus Diniz ^[3] ; Cescato, Valter Angelo ^[1] ; da Silva, Gilberto Ochman ^[1] ; Borba Herkenhoff, Clarissa G. ^[1] ; Cunha-Neto, Malebranche Berardo ^[1] ; Musolino, Nina Rosa ^[1]

Affiliation

^[1] Univ Sao Paulo HCFMUSP, Psychiat Inst Ipq, Funct Neurosurg Div, Sao Paulo - Brazil

^[2] Univ Sao Paulo HCFMUSP, Hosp Clin, Endocrinol Discipline, Mol & Cellular Lab LIM 25, Sao Paulo - Brazil

^[3] Univ Fed Santa Maria, Hlth Sci Ctr, Clin Med Dept, Santa Maria, RS - Brazil

• Document type: Journal article
• Source: WORLD NEUROSURGERY; v. 120, p. E241-E246, DEC 2018.
• Web of Science Citations: 1

Abstract

BACKGROUND: Tumor recurrence or incomplete resection in nonfunctioning pituitary adenomas (NFPAs) is relatively common. However, predictive factors of tumor recurrence in NFPAs are not well established. We evaluated possible factors related to tumor recurrence in a large cohort of NFPAs at a single pituitary neurosurgery center. METHODS: A retrospective analysis was conducted of medical records of patients with NFPAs treated by transsphenoidal surgery between 2000 and 2014. RESULTS: Among the participants, 210 were female A total of 14.1% had giant adenomas. Null-cell pituitary adenomas (n = 239; 58.9%) were the most frequent, followed by silent gonadotroph adenomas (n = 112; 27.3%). Null-cell adenomas were more frequent in women (P = 0.008) and silent gonadotroph adenomas were more frequent in men (P = 0.004). Recurrence was not related to sex or age. Tumor recurrence occurred more often among silent corticotropic adenomas and giant adenomas (hazard ratio 2.45; P < 0.0001 and hazard ratio 2.35; P = 0.001, respectively). Silent thyrotrophic adenoma presented a comparable frequency of recurrence of silent corticotropic adenomas, despite having borderline significance (P = 0.07). CONCLUSIONS: NFPA tumors have a high heterogeneous hormonal profile and may have prognostic importance. Silent corticotropic adenomas and giant adenomas present a high rate of recurrence. (AU)

• FAPESP's process: 14/16327-1 - Expression of D2 receptor in clinically nonfunctioning pituitary adenomas and its correlation with cabergoline treatment
• Grantee: Ericka Barbosa Trarbach
• Support Opportunities: Regular Research Grants