Influence of weight loss on pulmonary function and levels of adipokines among asthmatic individuals with obesity: One-year follow-up

Author(s)

Baltieri, Leticia ^[1] ; Cazzo, Everton ^[1] ; de Souza, Aglecio Luiz ^[2] ; Alegre, Sarah Monte ^[2] ; Vieira, Rodolfo de Paula ^{[3, 4]} ; Antunes, Edson ^[5] ; de Mello, Glaucia Coelho ^[5] ; Martins, Luiz Claudio ^[2] ; Chaim, Elinton Adami ^[1]

Affiliation

^[1] Univ Estadual Campinas, Fac Med Sci, Dept Surg, Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Sao Paulo - Brazil

^[3] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Paulo - Brazil

^[4] Fed Univ Sao Paulo UNIFESP, Postgrad Program Sci Human Movement & Rehabil, Postgrad Program Bioengn & Biomed Engn, Univ Brasil, Sao Paulo - Brazil

^[5] Univ Estadual Campinas, Fac Med Sci, Dept Pharmacol, Sao Paulo - Brazil

• Document type: Journal article
• Source: RESPIRATORY MEDICINE; v. 145, p. 48-56, DEC 2018.
• Web of Science Citations: 5

Abstract

Background: Individuals with obesity are more likely to develop asthma, but the exact mechanism is still uncertain and several hypotheses have been raised, such as the release of inflammatory mediators secreted by adipose tissue. Objective: To assess the effects of weight loss in patients submitted to bariatric surgery on pulmonary and systemic inflammation. Method: The study evaluated patients undergoing bariatric surgery (Roux-en-Y gastric bypass) with the diagnosis of asthma, except smokers. The patients were evaluated at the time of entry into a preoperative weight loss group (T1), just before bariatric surgery (T2), six months after surgery (T3), and 12 months after surgery (T4). The following were measured: anthropometric data, dosage of systemic inflammatory markers by means of blood collection, pulmonary inflammatory markers obtained by induced sputum collection, pulmonary function parameters, and asthma activity assessed by a Asthma Control Test (ACT) questionnaire. Results: Nineteen patients participated in the study. There were significant reductions in the systemic levels of interleukin (IL)-8 (p = 0.002), C-reactive protein (CRP) (p = 0.003), leptin (p = 0.001) and tumor necrosis factor (TNF)-alpha (p = 0.007), and significant increase in the systemic levels of IL-6 (p = 0.004) over time and adiponectin in T2 (p = 0.025). In regards to pulmonary inflammation, there were significant reductions in the sputum levels of TNF-alpha (p < 0.001). There was no significant improvement of the pulmonary function parameters (p > 0.05) and significant improvement in asthma activity scores (p < 0.0001). Conclusion: Weight loss was associated with significant changes in the systemic and pulmonary inflammatory profiles of individuals with asthma, leading to a better asthma control as a result of an increase in some anti-inflammatory mediators and a reduction of pro-inflammatory mediators. (AU)

• FAPESP's process: 14/06293-2 - Effects of weight loss induced bariatric surgery in lung function and inflammatory profile of obese asthmatics
• Grantee: Elinton Adami Chaim
• Support Opportunities: Regular Research Grants