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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Treatment of obstructive sleep apnoea as primary or secondary prevention of cardiovascular disease: where do we stand now?

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Author(s):
Drager, Luciano F. [1, 2] ; Lee, Chi-Hang [3]
Total Authors: 2
Affiliation:
[1] Univ Sao Paulo, Med Sch, Hypertens Unit, Heart Inst InCor, Ave Dr Eneas Carvalho de Aguiar 44, BR-05403900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Med Sch, Hypertens Unit, Renal Div, Sao Paulo - Brazil
[3] Natl Univ Heart Ctr, Dept Cardiol, Singapore - Singapore
Total Affiliations: 3
Document type: Review article
Source: CURRENT OPINION IN PULMONARY MEDICINE; v. 24, n. 6, p. 537-542, NOV 2018.
Web of Science Citations: 3
Abstract

Purpose of review The aim of this study was to provide an update of the primary and secondary prevention of obstructive sleep apnoea (OSA) treatment on cardiovascular disease. Recent findings Consistent evidence suggest that OSA can contribute to cardiovascular diseases, including hypertension, atrial fibrillation, coronary artery disease and stroke. In patients with no previous history of cardiovascular events (primary prevention scenario), observational studies suggest that continuous positive airway pressure (CPAP), the main treatment for OSA, is able to prevent hypertension incidence and to decrease nonfatal cardiovascular events in men and fatal cardiovascular events in men, women and elderly. In patients with a previous history of cardiovascular events (secondary prevention scenario), recent randomized trials showed that CPAP was not able to prevent a new cardiovascular event. These findings may suggest that in patients with high cardiovascular risk and multiple comorbidities, OSA may not have an incremental role on cardiovascular disease. However, a subanalysis from the same trials showed that good CPAP compliance was able to prevent cerebrovascular events. Summary OSA may predispose to cardiovascular disease, but additional efforts for improving CPAP use or development of new treatments may help to understand the magnitude of OSA on cardiovascular disease. (AU)

FAPESP's process: 12/02953-2 - Impact of obstructive sleep apnea and sleep duration on the progression of cardiovascular diseases
Grantee:Luciano Ferreira Drager
Support Opportunities: Research Grants - Young Investigators Grants