Glutathione peroxidase 4 functional variant rs713041 modulates the risk for cardiovascular autonomic neuropathy in individuals with type 1 diabetes

Author(s):Show less -

Admoni, Sharon Nina ^{[1, 2]} ; Santos-Bezerra, Daniele Pereira ^[1] ; Perez, Ricardo Vesoni ^{[1, 2]} ; Patente, Thiago Andrade ^[1] ; Monteiro, Maria Beatriz ^[1] ; Cavaleiro, Ana Mercedes ^[1] ; Parisi, Maria Candida ^[3] ; Neto, Arnaldo Moura ^[3] ; Pavin, Elizabeth Joao ^[3] ; Queiroz, Marcia Silva ^[2] ; Nery, Marcia ^[2] ; Correa-Giannella, Maria Lucia ^{[4, 1]}

Affiliation

^[1] Univ Sao Paulo, Fac Med, HCFMUSP, Lab Carboidratos & Radioimunoensaios LIM 18, Ave Dr Arnaldo 455 3321, BR-01246903 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Div Endocrinol, Sao Paulo - Brazil

^[3] Univ Estadual Campinas UNICAMP, Fac Med, Dept Clin Med, Div Endocrinol, Campinas, SP - Brazil

^[4] Univ Nove Julho Uninove, Programa Posgrad Med, Sao Paulo - Brazil

• Document type: Letter
• Source: Diabetes & Vascular Disease Research; v. 16, n. 3 JAN 2019.
• Web of Science Citations: 1

Abstract

Cardiac autonomic neuropathy is a neglected diabetic chronic complication for which genetic predictors are rarely reported. Oxidative stress is implicated in the pathogenesis of microvascular complications, and glutathione peroxidase 4 is involved in the detoxification of peroxides and of reactive oxygen species. Thus, the association of a functional variant in the gene encoding glutathione peroxidase 4 (rs713041) with this diabetic complication was investigated in 341 individuals with type 1 diabetes evaluated for cardiac autonomic neuropathy status (61.7% women, 34 {[}27-42] years old; diabetes duration: 21 {[}15-27] years; HbA1c: 8.3% {[}7.4-9.4]; as median {[}interquartile interval]). Cardiac autonomic neuropathy was present in 29% of the participants. There was an inverse association of the minor T allele of rs713041 with cardiac autonomic neuropathy (odds ratio = 0.39; 95% confidence interval = 0.17-0.90; p = 0.0271) after adjustment for potential confounders. The functional glutathione peroxidase 4 variant rs713041 modulated the risk for cardiac autonomic neuropathy in the studied population with type 1 diabetes. (AU)

• FAPESP's process: 12/25490-8 - Lower expression of advanced glycation endproduts receptor-1 (AGER1) in peripheral blood mononuclear cells is associated with renal disease in type 1 diabetes patients
• Grantee: Daniele Pereira dos Santos Bezerra
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 09/09276-3 - Study of Polymorphisms in Genes Coding Antioxidant Enzymes and Glucose Transporters and the Susceptibility to Chronic Complications in Type 1 Diabetic Patients
• Grantee: Maria Lucia Cardillo Corrêa Giannella
• Support Opportunities: Regular Research Grants