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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Etiologic role of root canal infection in apical periodontitis and its relationship with clinical symptomatology

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Author(s):
Brenda Paula Figueiredo de Almeida Gomes [1] ; Daniel Rodrigo Herrera [2]
Total Authors: 2
Affiliation:
[1] Universidade Estadual de Campinas –Unicamp. Piracicaba Dental School. Department of Restorative Dentistry - Brasil
[2] Universidade Estadual de Campinas –Unicamp. Piracicaba Dental School. Department of Restorative Dentistry - Brasil
Total Affiliations: 2
Document type: Journal article
Source: Brazilian Oral Research; v. 32, 2018-10-18.
Abstract

Abstract: Evidence shows the polymicrobial etiology of endodontic infections, in which bacteria and their products are the main agents for the development, progression, and dissemination of apical periodontitis. Microbial factors in necrotic root canals (e.g., endotoxin) may spread into apical tissue, evoking and supporting a chronic inflammatory load. Thus, apical periodontitis is the result of the complex interplay between microbial factors and host defense against invasion of periradicular tissues. This review of the literature aims to discuss the complex network between endodontic infectious content and host immune response in apical periodontitis. A better understanding of the relationship of microbial factors with clinical symptomatology is important to establish appropriate therapeutic procedures for a more predictable outcome of endodontic treatment. (AU)

FAPESP's process: 15/23479-5 - Microbiomes and immunobiological aspects in endodontic infections
Grantee:Brenda Paula Figueiredo de Almeida Gomes
Support Opportunities: Research Projects - Thematic Grants