Genetic polymorphism in RANK is associated with mandibular size

Author(s)

Kuchler, Erika Calvano ^[1] ; do Nascimento, Mariele Andrade ^[1] ; Nakane Matsumoto, Mirian Aiko ^[2] ; Romano, Fabio Lourenco ^[2] ; Bezerra da Silva, Raquel Assed ^[1] ; Omori, Marjorie Ayumi ^[1] ; Antunes, Livia Azeredo ^[3] ; Antunes, Leonardo Santos ^[3] ; Bezerra da Silva, Lea Assed ^[1] ; Nelson-Filho, Paulo ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Dent RibeiraoPreto, Dept Pediat Dent, Ave Cafe S-N, BR-14040904 Ribeirao Preto, SP - Brazil

^[2] Univ Sao Paulo, Sch Dent RibeiraoPreto, Orthodont Clin, Dept Pediat Dent, Ribeirao Preto - Brazil

^[3] Fluminense Fed Univ, Sch Dent, Dept Specif Format, Rio De Janeiro - Brazil

• Document type: Journal article
• Source: JOURNAL OF ORTHODONTICS; v. 45, n. 3, p. 157-162, 2018.
• Web of Science Citations: 0

Abstract

Objective: The aim of this study was to evaluate the association between genetic polymorphisms in RANK, RANKL and OPG with maxillary and mandibular dimensions in humans. Design: DNA extracted from saliva and the rs3826620, rs9594738 and rs2073618 polymorphisms in RANK, RANKL and OPG, respectively, were analysed by real-time PCR. Four linear measurements (Co-Gn, GoPg, Co-Go and PTM-A) from lateral cephalograms were examined for the evaluation of craniofacial measurements. ANOVA testing and a multivariate linear regression analysis, adjusted for age and gender, were used for statistical analysis, with an alpha of 5%. Hardy-Weinberg equilibrium was also evaluated using the chi-square test within each polymorphism. Setting: School of Dentistry of Ribeirao Preto, University of Sao Paulo. Participants: A total of 100 unrelated non-syndromic Brazilian Caucasian subjects were included in this study. Results: The polymorphism in RANK was associated with a higher Go-Pg measurement (p=.039). In the multivariate analysis, adjusted for age and gender, the polymorphism in RANK was associated with Go-Pg (p=.017) and Co-Gn (p=.043). Conclusion: The polymorphism rs3826620 in RANK is associated with the mandibular size. (AU)

• FAPESP's process: 16/08149-1 - Evaluation of the role of estrogen in dentofacial tissues
• Grantee: Erika Calvano Kuchler
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 16/13982-4 - Evaluation of the role of estrogen in the growth and development of the maxilla and mandible
• Grantee: Marjorie Ayumi Omori
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 15/06866-5 - Evaluation of the role of estrogen in dentofacial development
• Grantee: Erika Calvano Kuchler
• Support Opportunities: Research Grants - Young Investigators Grants