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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

IN VITRO Anticancer Activity and Physicochemical Properties of SOLANUM LYCOCARPUM Alkaloidic Extract Loaded in Natural Lipid-Based Nanoparticles

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Author(s):
Carvalho, I. P. S. [1] ; Miranda, M. A. [1] ; Silva, L. B. [1] ; Chrysostomo-Massaro, T. N. [1] ; Paschoal, J. A. R. [2] ; Bastos, J. K. [2] ; Marcato, P. D. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, NanoBioLab, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: COLLOID AND INTERFACE SCIENCE COMMUNICATIONS; v. 28, p. 5-14, JAN 2019.
Web of Science Citations: 3
Abstract

Bladder cancer (BC) is the 9th most common cancer in the worldwide. BC's treatment is still a challenging goal. Thereby, the screening of natural compounds as solasonine (SS) and solamargine (SM) that exhibit antitumor activity is interesting to BC therapy. This work aimed to develop natural lipid-based nanoparticles (NLN) as carrier system of S. lycocarpum's fruits alkaloidic extract (AE), rich in SS and SM, and to evaluate its antitumor activity in bladder cancer cells. The NLN-AE exhibited 56 nm of diameter, low polydispersity index with shelf life estimated of 12 months, measured by LUMiSizer (R). NLN-AE showed low recrystallization index with high encapsulation efficiency of SS (86%) and SM (89%). A sustained release profile was verified after 36 h. The free AE exhibited antitumor activity in bladder cancer cells. The cell viability decreased 5.4 fold when AE was encapsulated in NLN. Thus, NLN-AE has higher anti-proliferative activity than the free AE. (AU)

FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
Grantee:Maria Vitória Lopes Badra Bentley
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 14/16727-0 - Development of solid lipid nanoparticles as carrier system of glycoalkaloids of Solanum lycocarpum for bladder cancer therapy
Grantee:Ivana Pereira Santos Carvalho
Support Opportunities: Scholarships in Brazil - Master