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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Origin, tempo, and mode of the spread of DENV-4 Genotype IIB across the state of Sao Paulo, Brazil during the 2012-2013 outbreak

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Ortiz-Baez, Ayda Susana [1] ; Cunha, Marielton dos Passos [1] ; Vedovello, Danila [2] ; Colombo, Tatiana Elias [3] ; Nogueira, Mauricio Lacerda [3] ; Villabona-Arenas, Christian Julian [4, 5] ; de Andrade Zanotto, Paolo Marinho [1]
Total Authors: 7
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, Lab Evolucao Mol & Bioinformat, Sao Paulo, SP - Brazil
[2] Fac Med Jundiai, Dept Pediat, Lab Infectol Pediat, Jundiai, SP - Brazil
[3] Fac Med Sao Jose do Rio Preto, Sao Jose Do Rio Preto, SP - Brazil
[4] Univ Montpellier, Inst Rech Dev, Montpellier - France
[5] Univ Montpellier, Inst Biol Computat, Lab Informat Robot & Microelect Montpellier, Montpellier - France
Total Affiliations: 5
Document type: Journal article
Source: Memórias do Instituto Oswaldo Cruz; v. 114, 2019.
Web of Science Citations: 1

BACKGROUND Dengue virus type 4 (DENV-4) was first reported in Brazil in 1982 and since then no more cases were detected again in Brazil until 2010, when the virus was reintroduced. Over the following years, the virus spread to several Brazilian states and resulted in about 1,400,000 dengue cases, in 2013. The largest number of cases were documented in the Southeast macro-region. OBJECTIVES To determine the phylogeography of DENV-4 Genotype IIB strains isolated during the epidemics in 2012-2013 in Sao Paulo, Brazil, we aimed to contextualise the contribution of viruses sampled in different localities across the overall movement of DENV-4 in Brazil. METHODS Based on the envelope gene sequences retrieved from GenBank, we employed a Bayesian phylogeographic approach to assess the spatiotemporal dynamics of DENV-4 Genotype IIB in Sao Paulo, Brazil. FINDINGS The dispersal dynamics of DENV-4 Genotype IIB in Brazil indicated Rio de Janeiro and Mato Grosso states as the most likely routes toward Sao Paulo before the 2012-2013 outbreak. Likewise, Guaruja and Sao Jose do Rio Preto facilitated viral spread and transmission to other localities in the South and Southeast macro-regions in Brazil. CONCLUSIONS The spread pattern of DENV-4 Genotype IIB strains across the country supports two independent introductions of the virus in Sao Paulo in a short period of time. Furthermore, Sao Paulo appears to have played a pivotal role in the dissemination of DENV-4 to other locations in Brazil. (AU)

FAPESP's process: 16/08204-2 - Genetic and phylodynamics diversity of emerging and re-emerging arboviruses (DENV, ZIKV and CHIKV) in the Northeast and Southeast regions of Brazil, 2014-2016
Grantee:Marielton dos Passos Cunha
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 11/17071-2 - Phylogeography of urban outbreaks of dengue virus in Jundiaí and Guarujá in the State of São Paulo
Grantee:Christian Julián Villabona Arenas
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 13/25434-3 - Intra-host genetic diversity of Dengue virus type 4 strains from the municipality of Guarujá, São Paulo
Grantee:Ayda Susana Ortiz Baez
Support type: Scholarships in Brazil - Master