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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exposure to thiamethoxam during the larval phase affects synapsin levels in the brain of the honey bee

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Author(s):
Tavares, Daiana Antonia [1] ; Roat, Thaisa Cristina [1] ; Mathias Silva-Zacarin, Elaine Cristina [2] ; Ferreira Noceelli, Roberta Cornelio [3] ; Malaspina, Osmar [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Paulista UNESP, CEIS, Inst Biociencias, Campus Rio Claro, Rio Claro, SP - Brazil
[2] Univ Fed Sao Carlos UFSCar, Dept Biol, LEBA, Campus Sorocaba, Sorocaba, SP - Brazil
[3] Univ Fed Sao Carlos UFSCar, Dept Ciencias Nat Matemat & Educ, Ctr Ciencias Agr, Campus Araras, Araras, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY; v. 169, p. 523-528, MAR 2019.
Web of Science Citations: 3
Abstract

Thiamethoxam (TMX) is a neurotoxic insecticide widely used for insect pest control. TMX and other neonicotinoids are reported to be potential causes of honey bee decline. Due to its systematic action, TMX may be recovered in pollen, bee bread, nectar, and honey, which make bees likely to be exposed to contaminated diet. In this study, we used immunolabeling to demonstrate that sublethal concentrations of TMX decrease the protein levels of synapsin in the mushroom bodies (MBs) and the antennal lobes (ALs) of pupae and newly emerged worker bees that were exposed through the food to TMX during the larval phase. A decrease in the synapsin level was observed in the MBs of pupae previously exposed to 0.001 and 1.44 ng/mu L and in newly emerged bees previously exposed to 1.44 ng/mu L and no changes were observed in the optical lobes (OLs). In the ALs, the decrease was observed in pupae and newly emerged bees exposed to 1.44 ng/mu L. Because the MBs and ALs are brain structures involved in stimuli reception, learning, and memory consolidation and because synapsin is important for the regulation of neurotransmitter release, we hypothesize that exposure to sublethal concentrations of TMX during the larval stage may cause neurophysiological disorders in honey bees. (AU)

FAPESP's process: 12/01498-0 - Biochemical and immunohistochemistry of sublethal effects thiamethoxam on the Apis mellifera Hymenoptera, apidae) africanized
Grantee:Daiana Antonia Tavares
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 12/13370-8 - How is the reaction of the Apis mellifera brain to a sublethal dose of thiamethoxam?
Grantee:Thaisa Cristina Roat
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 12/50197-2 - Action of products used in cultivation of sugar cane on non-target organisms
Grantee:Carmem Silvia Fontanetti Christofoletti
Support Opportunities: Program for Research on Bioenergy (BIOEN) - Thematic Grants