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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Expression patterns of mesenchymal stem cell-specific proteins in adipose tissue-derived cells: possible immunosuppressing agent in partial allograft for restoring the urinary bladder in rabbits

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Pinto Filho, Saulo T. L. [1] ; Pillat, Micheli M. [2] ; Rosa, Matheus P. [1] ; Dalmolin, Fabiola [3] ; Ulrich, Henning [2] ; Pippi, Ney L. [1]
Total Authors: 6
[1] Univ Fed Santa Maria, Hosp Vet Univ, Dept Clin Pequenos Anim, Ave Roraima 1000, Predio 97, BR-97105900 Santa Maria, RS - Brazil
[2] Univ Sao Paulo, Dept Bioquim, Inst Quim, Ave Prof Lineu Prestes 748, BR-05508900 Sao Paulo, SP - Brazil
[3] Univ Fed Fronteira Sul, Campus Realeza, Rua Edmundo Gaievisk 1000, BR-85770000 Realeza, PR - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Pesquisa Veterinária Brasileira; v. 38, n. 12, p. 2183-2189, DEC 2018.
Web of Science Citations: 0

ABSTRACT: Adipose tissue-derived stem cells (ADSCs) are an attractive source of mesenchymal stem cells (MSCs) for use in tissue engineering and clinical applications. This paper focuses on the characterization of ADSCs used as immunosuppressive agent in rabbits undergoing partial allograft for urine bladder restorage. For this study highlighted the characterization of the ADSCs used as immunosuppressive agents in rabbits submitted to partial allograft for restoration of the urinary vesicle, using 25 animals, six months old, New Zealand. ADSCs at the third peal were characterized by the MSC-specific CD105, CD73 and CD90 expression and by the absence of the hematopoietic marker CD45, as revealed by flow cytometry analysis. Moreover, ADSCs were efficient in preventing allograft rejection from the urinary bladder, as judged by biochemical, clinical and ultrasonography analysis. Together, these results compose characterization of protein expression profiles and immunosuppressive functionality of ADSCs in rabbits, which had undergone partial allografts of the urinary bladder, foreseeing future applications in clinical practice. (AU)

FAPESP's process: 12/50880-4 - Stem cells: from basic studies of kinin and purinergic receptor roles towards therapeutical applications
Grantee:Alexander Henning Ulrich
Support type: Research Projects - Thematic Grants
FAPESP's process: 15/19478-3 - Role of kinin-B2 receptor in pathogenesis and progression of familial Alzheimer's Disease: from neurogenesis and immune response to cognition
Grantee:Micheli Mainardi Pillat
Support type: Scholarships in Brazil - Post-Doctorate