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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Linkage study of voltage-gated potassium channels in familial mesial temporal lobe epilepsy

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Author(s):
Cláudia Vianna Maurer-Morelli [1] ; Rafael Breglio Marchesini [2] ; Rodrigo Secolin [3] ; Neide Ferreira Santos [4] ; Eliane Kobayashi [5] ; Fernando Cendes [6] ; Iscia Lopes-Cendes [7]
Total Authors: 7
Affiliation:
[1] Universidade Estadual de Campinas. Department of Medical Genetics - Brasil
[2] Universidade Estadual de Campinas. Department of Medical Genetics - Brasil
[3] Universidade Estadual de Campinas. Department of Medical Genetics - Brasil
[4] Universidade Estadual de Campinas. Department of Medical Genetics - Brasil
[5] Universidade Estadual de Campinas. Department of Neurology
[6] Universidade Estadual de Campinas. Department of Neurology
[7] Universidade Estadual de Campinas. Department of Medical Genetics - Brasil
Total Affiliations: 7
Document type: Journal article
Source: Arquivos de Neuro-Psiquiatria; v. 65, n. 1, p. 20-23, 2007-03-00.
Abstract

Voltage-gated potassium channels (VGKCs) play a critical role in the regulation of neuronal excitability and have been implicated in some types of epilepsies. Recently, autoimmune limbic encephalitis (LE) was associated with antibodies against VGKC. In addition, patients with LE showed partial epilepsy and increased T2 signal abnormalities in limbic structures. We have reported familial mesial temporal lobe epilepsy (FMTLE) associated with hippocampal atrophy (HA) and other signs of mesial temporal sclerosis detected by magnetic resonance imaging (MRI). In order to investigate whether VGKC may be associated to HA present in FMTLE, we perform linkage study in these candidate genes. Seventy-three microsatellites markers were genotyped in different human autosomal chromosome. Two-point LOD scores did not show evidence for linkage with any of the microsatellite markers genotyped (Zmax ranging from 0.11to-9.53 at theta=0.00). In the present study, linkage data showed no evidence that VGKC are involved in the determination of HA in FMTLE. (AU)

FAPESP's process: 03/13424-1 - Identification and characterization of etiology, mechanisms of damage, neuronal dysfunction, and molecular defects in mesial temporal lobe epilepsy and its relationship with response to treatment
Grantee:Iscia Teresinha Lopes Cendes
Support Opportunities: Research Projects - Thematic Grants