Effect of different doses of nandrolone associated with resistance training on muscle phenotypic profi le and cross-sectional area of rats

Author(s)

Rozangela Verlengia ^[1] ; Jonato Prestes ^[2] ; Ricardo Yukio Asano ^[3] ; Wagner José da Silva ^[4] ; Gerson Eduardo Rocha de Campos ^[5] ; Cláudia Regina Cavaglieri ^[6] ; Rodrigo Duarte de Souza ^[7] ; Sérgio Ricardo Boff ^[8] ; Silvia Cristina Crepaldi Alves ^[9]

Affiliation

^[1] Universidade Metodista de Piracicaba. Faculdade de Ciências da Saúde

^[2] Universidade Católica de Brasília

^[3] Universidade Católica de Brasília

^[4] Universidade Metodista de Piracicaba. Faculdade de Ciências da Saúde

^[5] Universidade Metodista de Piracicaba. Faculdade de Ciências da Saúde

^[6] Universidade Estadual de Campinas. Faculdade de Educação Física

^[7] Universidade Metodista de Piracicaba. Faculdade de Ciências da Saúde

^[8] Universidade Metodista de Piracicaba. Faculdade de Ciências da Saúde

^[9] Universidade Metodista de Piracicaba. Faculdade de Ciências da Saúde

• Document type: Journal article
• Source: Revista Paulista de Educação Física; v. 27, n. 1, p. 83-90, 2013-03-00.

Abstract

The aim of the present study was to evaluate the influence of different doses of nandrolone decanoate (ND) associated with Strength Training (ST) on the phenotype of fibers and cross-sectional area (CSA) of the extensor digitorum longus (EDL) in Wistar rats. The animals were divided into seven groups: control (CG) and the groups according to the dose of ND administered (0,1, 1, 2, 5, 10 e 20 mg/kg). The ST consisted of water jumping with loads of 50-70% of their body mass, three times per week during five weeks. The association of ST with ND promoted a modulatory role on the muscle fiber types. There was a hypertrophy of fast twitch fibers (type II) as compared with slow twitch (type I). In conclusion, although the association of ST with ND increased muscle CSA and modified fiber phenotype, there was no additional effect of higher doses. (AU)