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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association study between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder

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Author(s):
Quirino Cordeiro [1] ; Carolina Cappi [2] ; Aline Santos Sampaio [3] ; Selma Aliotti Palácios ; Carlos Alberto de Bragança Pereira [5] ; Roseli Gedanke Shavitt [6] ; Eurípedes Constantino Miguel [7] ; Luiza Guilherme ; Ana Gabriela Hounie [9]
Total Authors: 9
Affiliation:
[1] Universidade de São Paulo. Medical School. Department and Institute of Psychiatry - Brasil
[2] Universidade de São Paulo. Medical School. Department and Institute of Psychiatry - Brasil
[3] Universidade de São Paulo. Medical School. Department and Institute of Psychiatry - Brasil
[5] Universidade de São Paulo. Institute of Mathematics and Statistics. Department of Statistics
[6] Universidade de São Paulo. Medical School. Department and Institute of Psychiatry - Brasil
[7] Universidade de São Paulo. Medical School. Department and Institute of Psychiatry - Brasil
[9] Universidade de São Paulo. Medical School. Department and Institute of Psychiatry - Brasil
Total Affiliations: 9
Document type: Journal article
Source: Revista Brasileira de Psiquiatria; v. 31, n. 2, p. 131-135, 2009-06-00.
Abstract

OBJECTIVE: Evidence from family and molecular genetic studies support the hypothesis of involvement of immunologic mechanisms in the pathophysiology of obsessive-compulsive disorder. The nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (NFKBIL1) has been suggested as a modulator of the immunological system. Given the importance of NFKBIL1 in the immunological response, the present study investigated the -62A/T polymorphism (rs2071592), located in the promoter region of its gene (NFKBIL1), as a genetic risk factor for the development of obsessive-compulsive disorder. METHOD: The -62A/T NFKBIL1 polymorphism was investigated in a sample of 111 patients who met DSM-IV criteria for obsessive-compulsive disorder and 272 healthy age- and gender-matched controls. RESULTS: There were no differences in genotypic distributions between patients and controls (χ2 = 0.98; 2 d.f.; p = 0.61). DISCUSSION: Despite these negative findings, more comprehensive polymorphism coverage within the NFKBIL1 is warranted in larger samples. Populations with different ethnic backgrounds should also be studied. CONCLUSION: The results of the present investigation do not provide evidence for the association between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder in this Brazilian sample. (AU)

FAPESP's process: 05/55628-8 - Phenotypic, genetic, immunological and neurobiological characterization of the obsessive compulsive disorder and its implications for treatment
Grantee:Eurípedes Constantino Miguel Filho
Support Opportunities: Research Projects - Thematic Grants