Violence as etiological factor on psychopathology of children. impact of intention...
Association of genetic variants and biological pathways across different psychiatr...
Full text | |
Author(s): |
Quirino Cordeiro
[1]
;
Carolina Cappi
[2]
;
Aline Santos Sampaio
[3]
;
Selma Aliotti Palácios
;
Carlos Alberto de Bragança Pereira
[5]
;
Roseli Gedanke Shavitt
[6]
;
Eurípedes Constantino Miguel
[7]
;
Luiza Guilherme
;
Ana Gabriela Hounie
[9]
Total Authors: 9
|
Affiliation: | [1] Universidade de São Paulo. Medical School. Department and Institute of Psychiatry - Brasil
[2] Universidade de São Paulo. Medical School. Department and Institute of Psychiatry - Brasil
[3] Universidade de São Paulo. Medical School. Department and Institute of Psychiatry - Brasil
[5] Universidade de São Paulo. Institute of Mathematics and Statistics. Department of Statistics
[6] Universidade de São Paulo. Medical School. Department and Institute of Psychiatry - Brasil
[7] Universidade de São Paulo. Medical School. Department and Institute of Psychiatry - Brasil
[9] Universidade de São Paulo. Medical School. Department and Institute of Psychiatry - Brasil
Total Affiliations: 9
|
Document type: | Journal article |
Source: | Revista Brasileira de Psiquiatria; v. 31, n. 2, p. 131-135, 2009-06-00. |
Abstract | |
OBJECTIVE: Evidence from family and molecular genetic studies support the hypothesis of involvement of immunologic mechanisms in the pathophysiology of obsessive-compulsive disorder. The nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 (NFKBIL1) has been suggested as a modulator of the immunological system. Given the importance of NFKBIL1 in the immunological response, the present study investigated the -62A/T polymorphism (rs2071592), located in the promoter region of its gene (NFKBIL1), as a genetic risk factor for the development of obsessive-compulsive disorder. METHOD: The -62A/T NFKBIL1 polymorphism was investigated in a sample of 111 patients who met DSM-IV criteria for obsessive-compulsive disorder and 272 healthy age- and gender-matched controls. RESULTS: There were no differences in genotypic distributions between patients and controls (χ2 = 0.98; 2 d.f.; p = 0.61). DISCUSSION: Despite these negative findings, more comprehensive polymorphism coverage within the NFKBIL1 is warranted in larger samples. Populations with different ethnic backgrounds should also be studied. CONCLUSION: The results of the present investigation do not provide evidence for the association between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder in this Brazilian sample. (AU) | |
FAPESP's process: | 05/55628-8 - Phenotypic, genetic, immunological and neurobiological characterization of the obsessive compulsive disorder and its implications for treatment |
Grantee: | Eurípedes Constantino Miguel Filho |
Support Opportunities: | Research Projects - Thematic Grants |