Natural products from the marine sponges Aaptos sp. and Hymeniacidon aff. heliophila, and from the nudibranch Doris aff. verrucosa

Author(s)

Ana Claudia Granato ^[1] ; Roberto G. S. Berlinck ^[2] ; Alviclér Magalhães ^[3] ; Alexandre B. Schefer ^[4] ; Antonio G. Ferreira ^[5] ; Bianca de Sanctis ^[6] ; José Carlos de Freitas ^[7] ; Eduardo Hajdu ^[8] ; Alvaro E. Migotto ^[9]

Affiliation

^[1] Universidade de São Paulo. Instituto de Química de São Carlos

^[2] Universidade de São Paulo. Instituto de Química de São Carlos

^[3] Universidade Federal de São Carlos. Departamento de Química

^[4] Universidade Federal de São Carlos. Departamento de Química

^[5] Universidade Federal de São Carlos. Departamento de Química

^[6] Universidade de São Paulo. Centro de Biologia Marinha

^[7] Universidade de São Paulo. Centro de Biologia Marinha

^[8] Universidade de São Paulo. Centro de Biologia Marinha

^[9] Universidade de São Paulo. Centro de Biologia Marinha

• Document type: Journal article
• Source: Química Nova; v. 23, n. 5, p. 594-599, 2000-10-00.

Abstract

Herein we describe the isolation of homarine and piridiniumbetaine B from the sponge Aaptos sp. Although homarine has a common occurrence among animals, piridiniumbetaine B was only recently isolated from the marine sponge Agelas dispar. The isolation of piridiniumbetaine B from two taxonomically distant marine sponges corroborate previous assumptions that such betaines should be regarded rather as primary metabolites. We have also isolated (9-[5'-(methylthio)-beta-D-xylofuranosyl]adenine (xylosyl-MTA) from the mantle of a nudibranch identified as Doris aff. verrucosa. The occurrence of xylosyl-MTA in the mantle of this animal strongly suggests that it is the same nudibranch species described for the Mediterranean sea. We have been unable to detect any other compound in the mantle extract of D. aff. verrucosa other than xylosil-MTA and sterols. GC-MS analysis of the sterol fraction from the nudibranch and its prey, the sponge Hymeniacidon aff. heliophila, revealed the occurrence of the ubiquitous sterols, cholesterol, brassicasterol, cholestanol, 24-methylcholesterol and 24-ethylcholesterol, as the only common metabolites, therefore precluding any assumption concerning the sequestration of secondary metabolites by the nudibranch from H. aff. heliophila. (AU)

• FAPESP's process: 96/04316-5 - Renewable marine resources of São Paulo State coast. Porifera (Demospongiae) and Chordata (Tunicata): taxonomy, chemistry and pharmacology
• Grantee: José Carlos de Freitas
• Support Opportunities: Research Projects - Thematic Grants