Influence of AIDS antiretroviral therapy on the growth pattern

Author(s)

Brigatto Simoes Golucci, Ana Paula ^[1] ; Lima Marson, Fernando Augusto ^{[1, 2]} ; Fedato Valente, Mariana Freitas ^[3] ; Branco, Maira Migliari ^[3] ; Prado, Camila Carbone ^[3] ; Negrao Nogueira, Roberto Jose ^{[1, 4]}

Affiliation

^[1] Univ Estaduade Campinas UNICAMP, Fac Ciencias Med, Dept Pediat, Campinas, SP - Brazil

^[2] Univ Estaduade Campinas UNICAMP, Fac Ciencias Med, Dept Med Genet, Campinas, SP - Brazil

^[3] Univ Estaduade Campinas UNICAMP, Fac Ciencias Med, Hosp Clin, Campinas, SP - Brazil

^[4] Fac Sao Leopoldo Mand, Campinas, SP - Brazil

• Document type: Review article
• Source: Jornal de Pediatria; v. 95, n. 1, p. 7-17, JAN-FEB 2019.
• Web of Science Citations: 4

Abstract

Objectives: Human immunodeficiency virus infection can result in the early impairment of anthropometric indicators in children and adolescents. However, combined antiretrovirat therapy has improved, in addition to the immune response and viral infection, the weight and height development in infected individuals. Therefore, the objective was to evaluate the effect of combined antiretroviral on the growth development of human immunodeficiency virus infected children and adolescents. Source of data: A systematic review was performed. In the study, the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) strategy was used as the eligibility criterion. The MEDLINE-PubMed and LILACS databases were searched using these descriptors: HIV, children, growth, antiretroviral therapy. The objective was defined by the population, intervention, comparison/control, and outcome (PICO) technique. Inclusion and exclusion criteria were applied for study selection. Synthesis of data: Of the 549 studies indexed in MEDLINE-PubMed and LILACS, 73 were read in full, and 44 were included in the review (33 showed a positive impact of combined antiretroviral therapy on weight/height development, ten on weight gain, and one on height gain in children and adolescents infected with human immunodeficiency virus). However, the increase in growth was not enough to normalize the height of infected children when compared to children of the same age and gender without human immunodeficiency virus infection. Conclusions: Combined antiretroviral therapy, which is known to play a role in the improvement of viral and immunological markers, may influence in the weight and height development in children infected with human immunodeficiency virus. The earlier the infection diagnosis and, concomitantly, of malnutrition and the start of combined antiretrovirat therapy, the lower the growth impairment when compared to healthy children. (C) 2018 Published by Elsevier Editora Ltda. on behalf of Sociedade Brasileira de Pediatria. (AU)

• FAPESP's process: 15/12858-5 - Identification of prevalent mutations and clinical and functional characterization of children and adults with primary ciliary dyskinesia
• Grantee: Fernando Augusto de Lima Marson
• Support type: Scholarships in Brazil - Post-Doctorate