Natural Antioxidants as Detoxifying Agents for Aflatoxins in Animal Feed

Author(s)

Neeff, D. V. ; Carao, A. C. R. ^[1] ; Goncalves, B. L. ^[2] ; Bordin, K. ^[3] ; Corassin, C. H. ^[2] ; Ledoux, D. R. ^[4] ; Rottinghaus, G. E. ^[5] ; Oliveira, C. A. F. ^[2]

Affiliation

^[1] Univ Sao Paulo, Dept Anim Prod & Nutr, Sch Vet Med & Anim Sci, Av Duque Caxias Norte 225, Pirassununga, SP - Brazil

^[2] Univ Sao Paulo, Dept Food Engn, Sch Anim Sci & Food Engn, Av Duque Caxias Norte 225, BR-13630000 Pirassununga, SP - Brazil

^[3] Pontificia Univ Catolica Parana, Sch Life Sci, Rua Imaculada Conceicao, BR-1155 Curitiba, PR - Brazil

^[4] Univ Missouri, Anim Sci Dept, Columbia, MO 65211 - USA

^[5] Univ Missouri, Coll Vet Med, Columbia, MO 65211 - USA

• Document type: Review article
• Source: ANIMAL NUTRITION AND FEED TECHNOLOGY; v. 18, n. 2, p. 281-295, MAY 2018.
• Web of Science Citations: 0

Abstract

Aflatoxins are secondary metabolites produced by fungi species of Aspergillus, mainly A. flavus, A. parasiticus and A. nomius. Aflatoxin B-1 (AFB(1)) is the most toxic compound, being hepatotoxic and carcinogenic in vertebrate animals including humans. The mechanisms of toxicity of AFB(1) include oxidative stress, which leads to DNA, protein and lipid damages at the cell level. Antioxidants have been used as food additives to protect against oxidative degradation, and are also known to inhibit fungal growth. This review presents the updated knowledge on the use of natural antioxidants as detoxifying agentsfor animal feed contaminated with aflatoxin. (AU)

• FAPESP's process: 13/13592-3 - Effects of aflatoxin, fumonisin and curcumin, alone or in combination, on the humoral immune response and determination of biotrnsformation products in broiler chickens
• Grantee: Diane Valganon de Neeff
• Support Opportunities: Scholarships in Brazil - Doctorate