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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Suppression of Prolactin Secretion Partially Explains the Antidiabetic Effect of Bromocriptine in ob/ob Mice

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Furigo, Isadora C. [1] ; Suzuki, Miriam F. [2] ; Oliveira, Joao E. [2] ; Ramos-Lobo, Angela M. [1] ; Teixeira, Pryscila D. S. [1] ; Pedroso, Joao A. [1] ; de Alencar, Amanda [1] ; Zampieri, Thais T. [1] ; Buonfiglio, Daniella C. [1] ; Quaresma, Paula G. F. [1, 3] ; Prada, Patricia O. [4] ; Bartolini, Paolo [2] ; Soares, Carlos R. J. [2] ; Donato, Jr., Jose [1]
Total Authors: 14
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo, SP - Brazil
[2] CNEN SP, IPEN, Biotechnol Ctr, BR-05508000 Sao Paulo, SP - Brazil
[3] Univ Estadual Campinas, Dept Internal Med, BR-13083887 Sao Paulo, SP - Brazil
[4] Univ Estadual Campinas, Sch Appl Sci, BR-13484350 Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Endocrinology; v. 160, n. 1, p. 193-204, JAN 2019.
Web of Science Citations: 1

Previous studies have shown that bromocriptine mesylate (Bromo) lowers blood glucose levels in adults with type 2 diabetes mellitus; however, the mechanism of action of the antidiabetic effects of Bromo is unclear. As a dopamine receptor agonist, Bromo can alter brain dopamine activity affecting glucose control, but it also suppresses prolactin (Prl) secretion, and Prl levels modulate glucose homeostasis. Thus, the objective of the current study was to investigate whether Bromo improves insulin sensitivity via inhibition of Prl secretion. Male and female ob/ob animals (a mouse model of obesity and insulin resistance) were treated with Bromo and/or Prl. Bromo-treated ob/ob mice exhibited lower serum Prl concentration, improved glucose and insulin tolerance, and increased insulin sensitivity in the liver and skeletal muscle compared with vehicle-treated mice. Prl replacement in Bromo-treated mice normalized serum Prl concentration without inducing hyperprolactinemia. Importantly, Prl replacement partially reversed the improvements in glucose homeostasis caused by Bromo treatment. The effects of the Prl receptor antagonist G129R-hPrl on glucose homeostasis were also investigated. We found that central G129R-hPrl infusion increased insulin tolerance of male ob/ob mice. In summary, our findings indicate that part of Bromo effects on glucose homeostasis are associated with decrease in serum Prl levels. Because G129R-hPrl treatment also improved the insulin sensitivity of ob/ob mice, pharmacological compounds that inhibit Prl signaling may represent a promising therapeutic approach to control blood glucose levels in individuals with insulin resistance. (AU)

FAPESP's process: 13/25032-2 - The role of SOCS3 in the control of hyperphagia, body weight regain and gluconeogenesis after a period of food restriction
Grantee:João Alfredo Bolivar Pedroso
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/11752-6 - Study of leptin functions during intrauterine and childhood stages in mice
Grantee:Angela Maria Ramos Lobo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/10992-6 - Investigation of metabolic programming through different approaches
Grantee:Jose Donato Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 12/15517-6 - Involvment of molecular factors in metabolic changes during pregnancy: role of SOCS3
Grantee:Thais Tessari Zampieri
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/21722-4 - Mechanism of action of bromocriptine and prolactin antagonists in the treatment of Diabetes and Obesity
Grantee:Isadora Clivatti Furigo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/25281-3 - Effects of growth hormone on POMC, cholinergic and hypothalamic paraventricular nucleus neurons: implications for energy and glycemic metabolism control
Grantee:Paula Gabriele Fernandes Quaresma Bergonsi
Support Opportunities: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/24345-4 - Evaluation of the potential of prolactin antagonists to the treatment of obesity and Diabetes mellitus 2
Grantee:Carlos Roberto Jorge Soares
Support Opportunities: Regular Research Grants