| Full text | |
| Author(s): |
Total Authors: 3
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| Affiliation: | [1] Univ Estadual Campinas, Inst Quim, Dept Quim Organ, BR-13084971 Campinas, SP - Brazil
Total Affiliations: 1
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| Document type: | Journal article |
| Source: | Journal of the Brazilian Chemical Society; v. 30, n. 4, p. 772-779, APR 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
A biocatalytic cascade process was developed using immobilized cells of the wild type yeast Candida albicans CCT 0776 in calcium alginate beads and a commercially available ketoreductase. The aim was to promote deracemization by stereoinversion of (±)-1-arylethanols in high substrate concentration (above 100 mmol L-1) to prepare the (R)-enantiomers of the alcohols (90-99%), with a high enantiomeric excess (83-99%) after 2 to 19 h. The (R)-1-(3-methoxyphenyl)ethanol, with 70% yield and 91% ee, obtained after 5 h was used to prepare (S)-1-(3-methoxyphenyl)-ethylamine with 60% yield and 91% ee after two steps, a key intermediate in the synthesis of (S)-rivastigmine. (AU) | |
| FAPESP's process: | 16/12074-7 - Biocatalysis in Organic Synthesis Using Whole Cells of Microorganisms and Isolated Enzymes |
| Grantee: | José Augusto Rosário Rodrigues |
| Support Opportunities: | Regular Research Grants |