Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Deracemization of sec-Alcohols through Sequential Application of C. albicans and Ketoreductases

Full text
Author(s):
Nasario, Fabio D. [1] ; Moran, Paulo J. S. [1] ; Rodrigues, Jose Augusto R. [1]
Total Authors: 3
Affiliation:
[1] Univ Estadual Campinas, Inst Quim, Dept Quim Organ, BR-13084971 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 30, n. 4, p. 772-779, APR 2019.
Web of Science Citations: 0
Abstract

A biocatalytic cascade process was developed using immobilized cells of the wild type yeast Candida albicans CCT 0776 in calcium alginate beads and a commercially available ketoreductase. The aim was to promote deracemization by stereoinversion of (+/-)-1-arylethanols in high substrate concentration (above 100 mmol L-1) to prepare the (R)-enantiomers of the alcohols (90-99%). with a high enantiomeric excess (83-99%) after 2 to 19 h. The (R)-1-(3-methoxyphenyl)ethanol, with 70% yield and 91% ee, obtained after 5 h was used to prepare (S)-1-(3-methoxyphenyl)-ethylamine with 60% yield and 91% ee after two steps. a key intermediate in the synthesis of (S)-rivastigmine. (AU)

FAPESP's process: 16/12074-7 - Biocatalysis in Organic Synthesis Using Whole Cells of Microorganisms and Isolated Enzymes
Grantee:José Augusto Rosário Rodrigues
Support type: Regular Research Grants